The role of sex hormones in the growth of antler bone tissue. I: Endocrine and metabolic effects of antiandrogen therapy

The Journal of Experimental Zoology
G A BubenikD A Wilson

Abstract

Cyproterone acetate (CA), an antiandrogenic compound, was used in order to investigate the role of testosterone in bone growth processes. The formation of Haversian systems in the growing antlers of white-tailed deer (Odocoileus virginianus) were substantially affected by only 3.5 mg of CA kg/wk. The mineralization processes of the bone matrix were almost completely blocked and the antlers persisted in growing throughout the whole year. Plasma levels of thyroxine, alkaline phosphatase and GH were higher while cortisol and testosterone levels were lower than in controls. No differences were registered in plasma levels of Ca, P or urea nitrogen. Despite hypertrophy of interstitial tissue, spermatogenesis was almost completely blocked. The sexual behaviour and the body appearance of experimental animals was typical for castrates.

References

Jan 1, 1975·Endocrinology·G A BubenikL J Grota
Oct 1, 1975·Canadian Journal of Physiology and Pharmacology·G A BubenikD I Wilson
Oct 1, 1972·Journal of Wildlife Diseases·R G MarburgerK A Clark
Jan 1, 1973·Journal of Reproduction and Fertility·A B Lakshman, P Isaac
Jan 1, 1971·Gynecologic Investigation·F Neumann
Jan 1, 1971·Gynecologic Investigation·R G van Wayjen, A van den Ende
Apr 1, 1971·The Journal of Clinical Endocrinology and Metabolism·R P KelchR B Jaffe
Aug 1, 1965·The Journal of Experimental Zoology·A B Bubenik, R Pavlansky
Oct 1, 1966·Journal of Reproduction and Fertility·R V Short, T Mann
Feb 3, 1967·Science·G J Bloch, J M Davidson
Feb 1, 1964·The Journal of Clinical Endocrinology and Metabolism·B E MURPHY, C J PATTEE

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Citations

Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·G A BubenikJ F Leatherland
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·G A Bubenik, D Schams
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·H J Rolf, K Fischer
Jul 5, 2006·Environmental Health Perspectives·D N Rao VeeramachaneniJames P Jacobson
Jun 14, 2005·Current Topics in Developmental Biology·Joanna PriceSteve Allen
Feb 22, 2002·The Journal of Experimental Zoology·George A BubenikFernando Koerner
Feb 24, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·George A BubenikGlen J van der Kraak
Jul 1, 1993·The Journal of Experimental Zoology·U KierdorfK Fischer
Feb 1, 1995·The Journal of Experimental Zoology·J M SuttieI D Corson
Feb 1, 1982·The Journal of Experimental Zoology·G A BubenikA G Binnington
May 1, 1977·Calcified Tissue Research·G R Delling, A Schulz
Nov 4, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Uwe KierdorfHans J Rolf

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