The Role of Sex-Specific Risk Factors in the Risk Assessment of Atherosclerotic Cardiovascular Disease for Primary Prevention in Women.

Current Atherosclerosis Reports
Priya M FreaneyNeil J Stone

Abstract

Robust evidence is emerging regarding the contribution of sex-specific risk factors to a woman's unique risk of atherosclerotic cardiovascular disease (ASCVD). This review summarizes the available literature regarding the association of sex-specific risk factors and ASCVD in women. The American College of Cardiology and American Heart Association Guidelines recommend estimation of 10-year risk of a first ASCVD event using the 2013 Pooled Cohort Equations. This can be further personalized by identifying sex-specific risk factors present in a woman's history. There are multiple vulnerable periods across a woman's life course that are associated with increased risk of ASCVD. Risk factors across the reproductive life course that have been shown to correlate with higher risk for future ASCVD include early menarche, adverse pregnancy outcomes (such as pre-eclampsia or preterm birth), and early natural or surgical menopause. In addition, certain conditions that are more common among women, including autoimmune diseases, history of chest irradiation, and certain chemotherapies, also need to be considered. Finally, risk assessment can be refined with subclinical disease imaging (coronary calcium score) if there remains uncertainty about...Continue Reading

References

Dec 19, 2003·The New England Journal of Medicine·Mary J RomanJane E Salmon
Dec 19, 2003·The New England Journal of Medicine·Yu AsanumaC Michael Stein
Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Femke AtsmaYvonne T van der Schouw
Jan 20, 2010·Journal of the American College of Cardiology·Karen A MatthewsKim Sutton-Tyrrell
Jun 15, 2012·The New England Journal of Medicine·Øjvind LidegaardNiels Keiding
Feb 12, 2013·European Journal of Epidemiology·Morven Caroline BrownRuth Bell
Mar 29, 2013·Circulation·Mattis Flyvholm RantheHeather A Boyd
Jun 27, 2013·American Journal of Obstetrics and Gynecology·Roy KessousEyal Sheiner
Sep 24, 2013·American Journal of Obstetrics and Gynecology·Cheryl L RobbinsWilliam M Callaghan
Mar 13, 2014·Journal of the American College of Cardiology·Raheel AhmedVijay Kunadian
Mar 19, 2014·Journal of the American College of Cardiology·Allan D SnidermanSergio Fazio
Feb 1, 2015·Annals of the Rheumatic Diseases·Elena MyasoedovaCynthia S Crowson
Oct 23, 2015·Current Treatment Options in Cardiovascular Medicine·Yu XiePuja K Mehta
Oct 30, 2015·Circulation·Samuel S GiddingUNKNOWN American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascula
Aug 12, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·J A LaveryC V Ananth
Oct 26, 2016·American Journal of Hematology·Joseph J ShatzelThomas G DeLoughery
Dec 2, 2017·BMJ : British Medical Journal·Martin den HeijerLouis Gooren
Feb 14, 2018·Circulation·Laxmi S MehtaUNKNOWN American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Card
Feb 27, 2018·Clinical Cardiology·Reto Daniel Kurmann, Rekha Mankad
Jun 14, 2018·The New England Journal of Medicine·Sharon H Giordano
Jul 7, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·L BrouwersB B van Rijn
Aug 1, 2018·European Journal of Epidemiology·Simon TimpkaJanet W Rich-Edwards
Aug 26, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·J HornJ W Rich-Edwards
Sep 8, 2018·Journal of the American College of Cardiology·Jennifer J StuartJanet W Rich-Edwards

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.