The role of shrimp miR-965 in virus infection

Fish & Shellfish Immunology
Le ShuXiaobo Zhang


RNAi, mediated by microRNAs (miRNAs), has attracted increasing attention for its important role in cross-talk between host and virus. However, the role of host miRNA in the virus infection in vivo has not been intensively investigated. In this study, the effects of a shrimp miRNA (miR-965) on the white spot syndrome virus (WSSV) infection were characterized. The results indicated that the expression of miR-965 was significantly upregulated in shrimp in response to the WSSV challenge, suggesting its involvement in the virus infection. The miR-965 silencing led to significant increases of WSSV copies and virus-infected shrimp mortality, while the miR-965 overexpression resulted in the decreased WSSV copies and virus-infected shrimp mortality, indicating that miR-965 played a negative role in the WSSV infection. The further data revealed that miR-965 inhibited the virus infection by targeting the viral wsv240 gene, an important gene required for the WSSV infection in shrimp. The results demonstrated that miR-965 could promote the shrimp phagocytosis against virus infection by targeting the shrimp ATG5 (autophagy related 5) gene. Therefore, our findings presented novel evidence to better understand the anfractuous host-virus intera...Continue Reading


Sep 17, 2004·Nature·Gunter Meister, Thomas Tuschl
Feb 24, 2005·Journal of the American Chemical Society·Lei ZengMing-Ming Zhou
Apr 23, 2005·Science·Charles-Henri LecellierOlivier Voinnet
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Feb 27, 2007·Science·Robinson TribouletMonsef Benkirane
Jul 23, 2008·Nature Immunology·David BaltimoreKonstantin D Taganov
May 20, 2009·Genes & Development·Jennifer L Umbach, Bryan R Cullen
Oct 23, 2009·Journal of Virology·Mazhar Hussain, Sassan Asgari
Jan 26, 2010·Nature Reviews. Immunology·Ryan M O'ConnellDavid Baltimore
Jun 18, 2010·Journal of Virology·Liping SongWenlin Huang
Feb 5, 2011·Antiviral Research·Shu-qi ZhengHua Tang
Aug 9, 2012·Antioxidants & Redox Signaling·Philip J Vernon, Daolin Tang
Aug 30, 2012·Journal of Proteome Research·Ting YeXiaobo Zhang
Sep 28, 2012·Journal of Virology·Tianzhi Huang, Xiaobo Zhang
Dec 20, 2013·Journal of Virology·Tianzhi HuangXiaobo Zhang

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms