The role of skin biopsy in differentiating small-fiber neuropathy from ganglionopathy

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
V ProviteraM Nolano

Abstract

We aimed to test the clinical utility of the leg:thigh intraepidermal nerve-fiber (IENF) density ratio as a parameter to discriminate between length-dependent small-fiber neuropathy (SFN) and small-fiber sensory ganglionopathy (SFSG) in subjects with signs and symptoms of small-fiber pathology. We retrospectively evaluated thigh and leg IENF density in 314 subjects with small-fiber pathology (173 with distal symmetrical length-dependent SFN and 141 with non-length-dependent SFSG). A group of 288 healthy subjects was included as a control group. The leg:thigh IENF density ratio was calculated for all subjects. We used receiver operating characteristic curve analyses to assess the ability of this parameter to discriminate between length-dependent SFN and SFSG, and the decision curve analysis to estimate its net clinical benefit. In patients with neuropathy, the mean IENF density was 14.8 ± 6.8/mm at the thigh (14.0 ± 6.9/mm in length-dependent SFN and 15.9 ± 6.7/mm in patients with SFSG) and 7.5 ± 4.5/mm at the distal leg (5.4 ± 3.2/mm in patients with length-dependent SFN and 10.1 ± 4.6/mm in patients with SFSG). The leg:thigh IENF density ratio was significantly (P < 0.01) lower in patients with length-dependent SFN (0.44 ± 0.2...Continue Reading

References

Sep 5, 2002·Muscle & Nerve·David Lacomis
Oct 4, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·K C GorsonA H Ropper
May 1, 1948·Journal of Neurology, Neurosurgery, and Psychiatry·D DENNY-BROWN
Jun 10, 2009·Brain : a Journal of Neurology·Jean-Philippe CamdessanchéJean-Christophe Antoine
Nov 4, 2009·Neurology·K KimpinskiP A Low
Nov 3, 2010·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaIngemar S J Merkies
Nov 16, 2010·The Journal of Urology·Yuanyuan LiangIan M Thompson
Aug 27, 2015·Journal of the Peripheral Nervous System : JPNS·Maria NolanoGiuseppe Lauria
Oct 16, 2015·Muscle & Nerve·Kelly G Gwathmey
Oct 24, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V ProviteraM Nolano
Oct 27, 2015·Frontiers in Aging Neuroscience·Peter NovakVera Novak
Jan 27, 2016·BMJ : British Medical Journal·Andrew J VickersEwout W Steyerberg
Oct 17, 2017·Clinical Interventions in Aging·Klara KomiciGiuseppe Rengo

❮ Previous
Next ❯

Citations

Aug 7, 2018·Current Opinion in Neurology·Claudia Sommer
Nov 16, 2018·Journal of Clinical Neuromuscular Disease·Joshua WeaverRussell L Chin
Sep 10, 2019·JAMA Neurology·Anne Louise Oaklander, Maria Nolano
Oct 26, 2018·Expert Review of Neurotherapeutics·Shunya NakaneYukio Ando
Jul 29, 2020·Canadian Journal of Pain = Revue Canadienne De La Douleur·Mary A Kelley, Anne Louise Oaklander
Oct 22, 2020·The New England Journal of Medicine·Anthony A Amato, Allan H Ropper
Dec 19, 2020·Brain Sciences·Maria NolanoVincenzo Provitera
Apr 17, 2021·Clinics in Geriatric Medicine·Lan Zhou
Mar 13, 2021·Brain : a Journal of Neurology·Troels S JensenBrian C Callaghan
Jul 1, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Luca LeonardiGiovanni Antonini
Aug 11, 2021·Muscle & Nerve·Franco GemignaniGiovanni Pavesi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.