The role of small intestinal bacterial overgrowth in cystic fibrosis: a randomized case-controlled clinical trial with rifaximin

Journal of Gastroenterology
Manuele FurnariRosaria Casciaro

Abstract

Scientific literature shows a high prevalence of Small Intestinal Bacterial Overgrowth (SIBO) in patients with Cystic Fibrosis (CF). The role of SIBO in nutritional status and gastrointestinal symptoms in CF is not known. Our aim was to study epidemiology and clinical impact of SIBO while assessing the efficacy of rifaximin in eradicating SIBO in CF patients. Symptoms questionnaire and Glucose Breath Test (GBT) were given to 79 CF patients (median age 19.6 years; 9.2-36.9). Subjects with a positive GBT were enrolled in a randomized controlled trial and received rifaximin 1200 mg for 14 days or no treatment. Questionnaire and GBT were repeated 1 month after the end of treatment or 45 days after the first negative GBT. Out of 79 patients, 25 were affected by SIBO (31.6%) with a significant correlation with lower BMI, SDS-BMI (p < 0.05) and serum albumin levels (p < 0.05), independently from pancreas insufficiency. Twenty-three patients took part in the randomized trial, 13 patients (56.5%) in rifaximin group and 10 patients (43.5%) in control group. Eradication rate of SIBO was 9/10 (90%) in rifaximin group and 2/6 (33.3%) in control group (p < 0.05). In the rifaximin group, gastrointestinal symptom improvement was observed in 4/...Continue Reading

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References

Oct 1, 1988·Gastroenterology·P Kerlin, L Wong
May 1, 1987·Journal of Pediatric Gastroenterology and Nutrition·Y BujanoverT Gilat
Aug 1, 1996·Alimentary Pharmacology & Therapeutics·S J LewisS J O'Keefe
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·P O StotzerH Abrahamsson
May 6, 1998·Journal of Paediatrics and Child Health·P J LewindonA J Martin
May 9, 2000·Archives of Disease in Childhood·R L SmythA Ferguson
Jul 2, 2002·The Journal of Pediatrics·Satti BeharryPeter Durie
Jan 12, 1961·The New England Journal of Medicine·G D DRUMMEYC M JONES
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lane L ClarkeNancy M Walker
Jan 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Oxana NorkinaRobert C De Lisle
Sep 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Drucy BorowitzJames Heubi
Oct 19, 2006·Journal of Gastroenterology·Satoru NaruseSusumu Takahashi
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Jacqueline L FridgeKenneth Cox
May 1, 2007·Clinics in Chest Medicine·Steven D Strausbaugh, Pamela B Davis
Mar 29, 2008·The American Journal of Gastroenterology·Jason R BrattenMichael P Jones
Jul 22, 2008·The Journal of Pediatrics·Philip M FarrellUNKNOWN Cystic Fibrosis Foundation
Feb 27, 2009·Expert Opinion on Investigational Drugs·Mark Pimentel
Jun 22, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Aleksandra LisowskaJarosław Walkowiak
Aug 14, 2010·Microbiology·Cecilia JernbergJanet K Jansson
Jul 20, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Aleksandra LisowskaJarosław Walkowiak
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Uday C Ghoshal
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Jan 29, 2013·Seminars in Arthritis and Rheumatism·Lorenzo GemignaniEdoardo Savarino
Mar 16, 2013·Journal of Pediatric Gastroenterology and Nutrition·Alisha J RovnerMaria R Mascarenhas
Sep 6, 2013·Alimentary Pharmacology & Therapeutics·S C ShahJ L Sewell
Oct 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard J Saad, William D Chey
Jan 31, 2014·Frontiers in Pediatrics·Tamara PangChee Y Ooi
Jan 13, 2015·European Radiology·Edoardo SavarinoLuca Maria Sconfienza
Jan 21, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A ErdoganC Badger
Feb 10, 2016·Clinics in Chest Medicine·Yvonne J Huang, John J LiPuma
Feb 12, 2017·BMC Medicine·Maarten R StruyvenbergSteven D Freedman
Mar 11, 2017·BMC Microbiology·D G BurkeR P Ross

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Citations

Nov 13, 2019·Pediatric Pulmonology·Kimberly AltmanKaren Maguiness
Sep 26, 2019·Frontiers in Pediatrics·David Avelar RodriguezEamonn Martin Quigley
Mar 25, 2021·Current Gastroenterology Reports·Samuel J BurtonJames M Abraham
Nov 13, 2021·Expert Review of Gastroenterology & Hepatology·Jinsheng WangXiaohua Hou
Jul 23, 2021·Journal of Pediatric Gastroenterology and Nutrition·Ilse Julia BroekaertMarc Benninga

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