The role of SMG-1 in nonsense-mediated mRNA decay

Biochimica Et Biophysica Acta
Akio YamashitaShigeo Ohno

Abstract

SMG-1, a member of the PIKK (phosphoinositide 3-kinase related kinases) family, plays a critical role in the mRNA quality control system termed nonsense-mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) that encode nonfunctional or potentially harmful truncated proteins. SMG-1 directly phosphorylates Upf1, another key component of NMD, and this phosphorylation occurs upon recognition of PTC on post-spliced mRNA during the initial round of translation. At present, a variety of tools are available that can specifically suppress NMD, and it is possible to examine the contribution of NMD in a variety of physiological and pathological conditions.

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J C Chang, Y W Kan
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R Losson, F Lacroute
May 1, 1992·Molecular and Cellular Biology·P LeedsM R Culbertson
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S L TheinD J Weatherall
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S J Baserga, E J Benz
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·B S Lee, M R Culbertson
Aug 18, 1994·Nature·D Muhlrad, R Parker
Oct 1, 1993·Genes & Development·R Pulak, P Anderson
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J EnssleA E Kulozik
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F HeA Jacobson
Jan 1, 1996·Annual Review of Biochemistry·A Jacobson, S W Peltz
Sep 1, 1996·The Plant Journal : for Cell and Molecular Biology·A van Hoof, P J Green
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·H A PerlickH C Dietz
Mar 10, 1998·Immunity·S Li, M F Wilkinson
Jun 17, 1998·The EMBO Journal·R ThermannA E Kulozik
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·X SunL E Maquat
Dec 23, 1998·Molecular & General Genetics : MGG·B M Cali, P Anderson
Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K CzaplinskiS W Peltz
Sep 2, 1999·Human Molecular Genetics·P A Frischmeyer, H C Dietz

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Citations

Nov 26, 2010·The Journal of Biological Chemistry·Fusako UsukiMasatake Fujimura
Mar 8, 2008·The Journal of Biological Chemistry·Vasco OliveiraRobert T Abraham
Sep 8, 2010·Nucleic Acids Research·Israel S FernándezOscar Llorca
Oct 4, 2011·Nucleic Acids Research·Yukiko Okada-KatsuhataShigeo Ohno
Jun 15, 2007·Molecular and Cellular Biology·Lisa JohnsPhilip Anderson
Jan 2, 2007·PLoS Genetics·Mark M Metzstein, Mark A Krasnow
Nov 8, 2013·Nucleic Acids Research·Clarivel LasaldeCarlos I González
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·David R McIlwainTak W Mak
Nov 5, 2013·Biochimica Et Biophysica Acta·Hana ChoYoon Ki Kim
Oct 28, 2009·Cellular and Molecular Life Sciences : CMLS·Pamela NicholsonOliver Mühlemann
Feb 5, 2016·Nature Communications·Roberto MeleroOscar Llorca
Nov 13, 2007·Biochimica Et Biophysica Acta·Romina MaroneMatthias P Wymann
Oct 3, 2012·Wiley Interdisciplinary Reviews. RNA·Lulu Huang, Miles F Wilkinson
Aug 21, 2013·Human Mutation·Maéva LangouëtLaurence Colleaux
Jun 20, 2006·Trends in Molecular Medicine·Holly A Kuzmiak, Lynne E Maquat
Sep 29, 2011·Biochimica Et Biophysica Acta·Taras Makhnevych, Walid A Houry
Oct 30, 2012·Current Opinion in Structural Biology·Oscar Llorca
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hana ChoYoon Ki Kim
Apr 17, 2012·Molecular Cell·Hana ChoYoon Ki Kim
Mar 15, 2015·Frontiers in Genetics·Patrick von MorgenLibor Macurek
May 18, 2016·Ageing Research Reviews·Yosef Shiloh, Howard M Lederman
Mar 14, 2007·Annual Review of Biochemistry·Yao-Fu ChangMiles F Wilkinson
Jun 30, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fusako UsukiShigeo Ohno
Aug 18, 2006·Molecular & Cellular Proteomics : MCP·Daniel BlanchardAndrew Fire
May 3, 2008·The EMBO Journal·Zoltán KerényiDániel Silhavy
Sep 26, 2009·The EMBO Journal·Harri Lempiäinen, Thanos D Halazonetis
Nov 17, 2009·Biochemical Society Transactions·Lynne E Maquat, Chenguang Gong
Nov 14, 2019·International Journal of Molecular Sciences·Umesh KalathiyaJavier Antonio Alfaro
Jan 30, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Akio Yamashita
Jul 9, 2013·Nature Structural & Molecular Biology·David ZündOliver Mühlemann
May 14, 2016·G3 : Genes - Genomes - Genetics·Kyle S HoffmanChristopher J Brandl

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