The Role of Social Relationships in PrEP Uptake and Use Among Transgender Women and Men Who Have Sex with Men

AIDS and Behavior
Megha MehrotraRobert M Grant

Abstract

Qualitative studies suggest that social relationships play an important role in HIV pre-exposure prophylaxis (PrEP) use, but there have been few quantitative assessments of the role of social relationships in PrEP uptake or adherence. We examined the association between disclosure of study participation or LGBT identity and PrEP use in the 1603 HIV-negative participants enrolled in the iPrEx OLE study. We also evaluated the association between LGBT social group involvement and PrEP use. Study participation disclosure to parents and LGBT identity disclosure to anyone in a participant's social network were associated with greater PrEP uptake. Study participation disclosure to partners was associated with higher probability of having protective PrEP drug concentrations compared [risk difference 0.15 95% CI (0.01, 0.30)]. For each additional type of LGBT organization a participant was involved in, the probability of PrEP uptake and having protective drug concentrations increased by 0.04 [95% CI (0.03, 0.06)] and 0.04 (95% CI (0.02, 0.07)] respectively. Overall, social context was associated with PrEP use in iPrEx OLE, and should be taken into consideration when designing future PrEP implementation programs.

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Citations

Feb 20, 2019·Journal of the International Association of Providers of AIDS Care·Jessica E HabererLinda-Gail Bekker
Jun 11, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tonia PoteatThespina Yamanis
Aug 5, 2020·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Arjee J RestarDon Operario
Jul 23, 2020·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Richard DunvilleStuart Michaels

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