The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

Redox Biology
Xu-Bo ChenWei-Jia Kong

Abstract

Age-related dysfunction of the central auditory system, known as central presbycusis, is characterized by defects in speech perception and sound localization. It is important to determine the pathogenesis of central presbycusis in order to explore a feasible and effective intervention method. Recent work has provided fascinating insight into the beneficial function of H2S on oxidative stress and stress-related disease. In this study, we investigated the pathogenesis of central presbycusis and tried to explore the mechanism of H2S action on different aspects of aging by utilizing a mimetic aging rat and senescent cellular model. Our results indicate that NaHS decreased oxidative stress and apoptosis levels in an aging model via CaMKKβ and PI3K/AKT signaling pathways. Moreover, we found that NaHS restored the decreased activity of antioxidants such as GSH, SOD and CAT in the aging model in vivo and in vitro by regulating CaMKKβ and PI3K/AKT. Mitochondria function was preserved by NaHS, as indicated by the following: DNA POLG and OGG-1, the base excision repair enzymes in mitochondrial, were upregulated; OXPHOS activity was downregulated; mitochondrial membrane potential was restored; ATP production was increased; and mtDNA damage...Continue Reading

Citations

Nov 24, 2017·Frontiers in Pharmacology·Minjun WangYi Zhun Zhu
May 24, 2018·BioMed Research International·José Sérgio Possomato-VieiraCarlos A Dias-Junior
Mar 13, 2020·Neurochemical Research·Yan YanHaibing Yu
Oct 19, 2020·Molecular Biology Reports·Michał SzewczukBolesław T Karwowski
Jan 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chaoyun WangChunxiang Zhang
Aug 3, 2021·BioMed Research International·Haiping DuanDongfeng Zhang

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Methods Mentioned

BETA
mechanical dissociation
Protein
electrophoresis
flow cytometry
Assay
fluorescence microscopy
PCR
protein folding

Software Mentioned

GeneQuant pro Calculator
Statistical Package for the Social Sciences ( SPSS )

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