PMID: 6107866Sep 1, 1980Paper

The role of sodium influx mediated by nicotinic receptors as an initial event in trans-synaptic induction of tyrosine hydroxylase in adrenergic neurons

Naunyn-Schmiedeberg's Archives of Pharmacology
H BönischH Thoenen

Abstract

1. Isolated superior cervical ganglia of the rat were incubated for 2--30 min (37 degrees C) in Krebs' solution or tissue culture medium (BGJb) containing 22Na and then washed for 30 min in ice-cold 22Na-free Krebs' solution (to clear extracellular space). The radioactivity remaining in the ganglia was taken as a measure of 22Na influx into the intracellular compartment of the ganglion. 2. Addition of cholinomimetics (100 microM nicotine or 100 microM carbachol) to the incubation led to an increase in 22Na influx. This increase reached maximal values after 10 min of incubation; it was more pronounced after incubation in Krebs' solution than in BGJb medium. 3. While chlorisondamine (3 microM) or dopamine (100 microM) greatly reduced the carbachol-induced 22Na influx, tetrodotoxin (2 microM) did not have any effect. 4. In ganglia obtained from animals treated with 6-hydroxydopamine in the early postnatal phase (resulting in an extensive destruction of peripheral sympathetic neurons) neither carbachol (100 microM) nor nicotine (100 microM) produced an increase in 22Na influx demonstrating that the intraneuronal compartment is responsible for this enhanced influx. 5. The effects of dopamine, chlorisondamine and tetrodotoxin on the ...Continue Reading

References

Mar 1, 1979·British Journal of Pharmacology·D A Brown, M P Caulfield
Oct 1, 1974·The Journal of Physiology·D A Brown, C N Scholfield
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P U Angeletti, R Levi-Montalcini
Jul 7, 1967·Biochemical Pharmacology·M LevittS Udenfriend

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Citations

Jan 1, 1989·Molecular Neurobiology·R Laufer, J P Changeux
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E F LaGammaI B Black
Sep 21, 1984·Science·I B BlackK M Markey

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