The role of some chemokines from the CXC subfamily in a mouse model of diabetic neuropathy

Journal of Diabetes Research
Magdalena ZychowskaJ Mika

Abstract

The mechanism involved in the development of diabetic neuropathy is complex. Currently, it is thought that chemokines play an important role in this process. The aim of this study was to determine how the level of some chemokines from the CXC subfamily varies in diabetic neuropathy and how the chemokines affect nociceptive transmission. A single intraperitoneal (i.p.) injection of streptozotocin (STZ; 200 mg/kg) resulted in an increased plasma glucose. The development of allodynia and hyperalgesia was measured at day 7 after STZ administration. Using Antibody Array techniques, the increases in CXCL1 (KC), CXCL5 (LIX), CXCL9 (MIG), and CXCL12 (SDF-1) protein levels were detected in STZ-injected mice. No changes in CXCL11 (I-TAC) or CXCL13 (BLC) protein levels were observed. The single intrathecal (i.t.) administration of CXCL1, CXCL5, CXCL9, and CXCL12 (each in doses of 10, 100, and 500 ng/5 μL) shows their pronociceptive properties as measured 1, 4, and 24 hours after injection using the tail-flick, von Frey, and cold plate tests. These findings indicate that the chemokines CXCL1, CXCL5, CXCL9, and CXCL12 are important in nociceptive transmission and may play a role in the development of diabetic neuropathy.

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Citations

Apr 11, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah HiyariFlavia Q Pirih
Sep 27, 2018·Endocrine Reviews·Gidon J BönhofDan Ziegler
Mar 28, 2019·Cadernos de saúde pública·Cristiane Vilas Boas NevesSérgio Viana Peixoto
Nov 28, 2019·Experimental and Therapeutic Medicine·Zhe ChenLei Xiang
May 1, 2021·International Journal of Clinical Practice·Pilar AscasoJosé T Real
Mar 3, 2020·European Journal of Pharmacology·Thamyris Reis MoraesGiovane Galdino

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Methods Mentioned

BETA
Antibody Array
electrophoresis
PCR
Protein Assay

Software Mentioned

iCycler IQ
Fujifilm Image Gauge

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