The role of SPARC expression in pancreatic cancer progression and patient survival

Scandinavian Journal of Gastroenterology
Chinmay GundewarDaniel Ansari

Abstract

Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that has been implicated in tumor-stroma interactions in pancreatic cancer. Here we evaluated the expression of SPARC during the progression of pancreatic cancer and its correlation with survival following curative intent surgery. The expression profile of SPARC was investigated in normal pancreas, invasive adenocarcinoma, and lymph node metastasis by immunohistochemistry. Kaplan-Meier and multivariate Cox regression were used to assess for mortality risk. None (0%) of 10 normal pancreata, 68 (77%) of 88 primary tumors, and 28 (67%) of 42 lymph node metastases were labeled with the SPARC antibody used in this study. SPARC was expressed exclusively in stromal cells. The survival of patients with high stromal SPARC expression was significantly worse than that of the patients with low stromal SPARC expression (11.5 vs 25.3 months; p = 0.020). Multivariate analysis showed that stromal SPARC expression (hazard ratio (HR) 2.12; p = 0.012), tumor location (body/tail) (HR 2.95; p = 0.003), and adjuvant chemotherapy (HR 0.55; p = 0.018) were significant independent risk factors. This study describes the pattern of SPARC expression in pancreatic neoplast...Continue Reading

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Citations

Oct 1, 2016·BioMed Research International·Javier Martinez-Useros, Jesus Garcia-Foncillas
Mar 7, 2017·Scientific Reports·S YadavalliP Kumar
Jun 17, 2020·Scandinavian Journal of Gastroenterology·Johannes ByrlingBodil Andersson
Mar 10, 2017·Scandinavian Journal of Gastroenterology·Daniel AnsariRoland Andersson
Oct 11, 2017·Cellular and Molecular Life Sciences : CMLS·Chen LiangXianjun Yu
Aug 28, 2018·World Journal of Gastrointestinal Oncology·Ozkan Kanat, Hulya Ertas
May 10, 2017·Molecular Oncology·Veronique L VeenstraMaarten F Bijlsma
Mar 18, 2016·International Journal of Oncology·Monica K RossiChristopher S Gondi
Jan 12, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Luciana MoscaGianni Colotti
Mar 3, 2020·Cancer Letters·Amanda MunasingheNatasha J Hill
Jan 17, 2019·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Ughur AghamaliyevKatja Breitkopf-Heinlein

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