The role of Src in colon cancer and its therapeutic implications

Clinical Colorectal Cancer
J ChenM Wasif Saif

Abstract

Src is a member of a superfamily of membrane-associated nonreceptor protein tyrosine kinases. It is stimulated by receptors of growth hormone, cytokines, and adipokines, and it regulates multiple signaling pathways, including phosphatidylinositide 3 kinase-Akt, mitogen-activated protein kinase, signal transducer and activator of transcription 3, interleukin 8, and vascular endothelial growth factor pathways, and cytoskeletal pathways to cause a cascade of cellular responses. Eighty percent of patients with colon cancer overexpress Src in tumor tissue. Evidence has shown that the overexpression of Src in colon cancer accelerates metastasis and causes chemotherapeutic drug resistance via multiple downstream signaling pathways. Therefore, the inhibition of Src may be useful for the treatment of colon cancer. However, the inhibition of Src may also weaken immune responses that are essential for the eradication of cancer cells. Overcoming the problem of inhibiting Src in cancer cells while retaining immune system efficacy is the key to the successful application of Src-inhibition therapy. Different Src family members are used by the immune system and colon cancer. This differential use may provide a good opportunity to develop Src f...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H OppermannJ M Bishop
Sep 1, 1992·The Journal of Clinical Investigation·T K WeberI C Summerhayes
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C A CartwrightW Eckhart
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J B BolenN Rosen
Jun 1, 1989·The Journal of Clinical Investigation·C A CartwrightW Eckhart
Feb 1, 1994·The Journal of Clinical Investigation·C A CartwrightB M Egbert
Jan 1, 1993·The Journal of Clinical Investigation·M S TalamontiG E Gallick
May 1, 1995·Molecular and Cellular Biology·J Park, C A Cartwright
Aug 18, 1994·Nature·P Rodriguez-VicianaJ Downward
Feb 7, 1998·The Journal of Biological Chemistry·J W ThomasM D Schaller
Jul 7, 1998·The Journal of Experimental Medicine·V W ChanA Tarakhovsky
Jun 8, 1999·Molecular Biology of the Cell·E Penuel, G S Martin
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·T NakagawaT Tsuruo
Dec 15, 2000·Oncogene·R B Irby, T J Yeatman
May 5, 2001·The Journal of Biological Chemistry·B D CuevasG B Mills
Sep 7, 2001·Cytokine & Growth Factor Reviews·K Xie
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Nov 7, 2002·Oncogene·T Christopher WindhamGary E Gallick
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Tzeng-Horng Leu, Ming-Chei Maa
Mar 22, 2003·Experimental Cell Research·Robert N JorissenAntony W Burgess
Nov 26, 2003·Biochemical Pharmacology·Tzeng-Horng LeuMing-Chei Maa
Jun 2, 2004·Nature Reviews. Cancer·Timothy J Yeatman
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Sep 24, 2004·Cancer Cell·Rumey Ishizawar, Sarah J Parsons
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katsuji SugieHoward M Grey
Nov 30, 2004·Science·Eric VivierFrédéric Vély
Jun 17, 2005·Cancer Research·Jennifer M GolasFrank Boschelli
Jul 12, 2005·Oncogene·Ami S BhattMark M Moasser
Aug 13, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Angels Sierra
Sep 1, 2005·The Journal of Cell Biology·Roumen PankovKenneth M Yamada
Oct 4, 2005·Biochimica Et Biophysica Acta·Yuh-Ping ChongHeung-Chin Cheng
Oct 18, 2005·American Journal of Surgery·Hiroe Shiratsuch, Marc D Basson

❮ Previous
Next ❯

Citations

Jul 23, 2014·BioMed Research International·Yu-Fei GaoYang Jiang
Aug 26, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Daniel Elias, Henrik J Ditzel
Mar 11, 2015·Reviews in Medical Virology·Jiezhong Chen
Sep 24, 2015·Seminars in Cancer Biology·Jürgen Dittmer
Apr 8, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L RamageE Tan
Mar 4, 2015·Nature·Koji TaniguchiMichael Karin
Dec 31, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Adam JedlinskiKarin Roberg
Jul 3, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Rie KokudaChitose Oneyama
Oct 1, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Liang YuHuiwu Li
Dec 5, 2019·Cancer Science·Daisuke OkuzakiChitose Oneyama
Apr 28, 2020·Biomolecules & Therapeutics·Md Jamal UddinHunjoo Ha
Apr 11, 2020·International Journal of Molecular Sciences·Joyce Nair-MenonAntonis Kourtidis
May 17, 2019·Journal of Drug Targeting·Mei-Lian CaiRong-Guang Shao
Jun 9, 2020·Frontiers in Molecular Biosciences·Deepak GurbaniKenneth D Westover
Mar 11, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine M ParseghianScott Kopetz
Aug 14, 2019·European Journal of Medicinal Chemistry·A GolonkoW Lewandowski
Jan 17, 2021·International Journal of Molecular Sciences·Osman AliJean-Pierre Raufman
May 1, 2021·Journal of Personalized Medicine·Diamanto SkopelitouObul Reddy Bandapalli

❮ Previous
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