PMID: 16507402Mar 2, 2006Paper

The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
J E Trosko

Abstract

Since carcinogenesis is a multi-stage, multi-mechanism process, involving mutagenic, cell death and epigenetic mechanisms, during the "initiation/promotion/and progression" phases, chemoprevention must be based on understanding the mechanism(s) of each phase. Prevention of each phase could reduce the risk to cancer. Because reducing the initiation phase to a zero level is impossible, the most effective intervention would be at the promotion phase. Assuming the "target" cells for carcinogenesis are the pluri-potent stem cells and their early progenitor or transit cells, chemoprevention strategies for inhibiting the promotion of these two types of pre-malignant "initiated" cells will require different agents. A hypothesis will be proposed that involves stem cells, which lack gap junctional intercellular communication (GJIC-) or their early progenitor daughter cells, which express GJIC+ and are partially-differentiated, if initiated, will be promoted by agents that either inhibit secreted negative growth regulators or by inhibitors of GJIC. Chemopreventing agents to each of these two types of initiated cells must have different mechanisms of action. Assuming stem cells are target cells for carcinogenesis, an alternative method of ...Continue Reading

References

Jul 14, 1966·Annals of the New York Academy of Sciences·W R Loewenstein
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·H C PitotS Moran
Nov 6, 1998·Science·J A ThomsonJ M Jones
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J ShamblottJ D Gearhart
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jul 20, 2002·Molecular Membrane Biology·W Howard Evans, Patricia E M Martin
Mar 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·John E Dick
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yi LiHarold E Varmus
Apr 20, 2004·Cardiovascular Research·Goran Söhl, Klaus Willecke

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Citations

Nov 13, 2008·Cytotechnology·Finbarr O'Sullivan, Martin Clynes
Apr 22, 2008·Stem Cell Reviews·James E Trosko
Apr 20, 2013·Neuropharmacology·Vytas K Verselis, Miduturu Srinivas
Jun 26, 2008·PloS One·Kelly E CorcoranPranela Rameshwar
Dec 17, 2015·Expert Opinion on Therapeutic Targets·Sajid KhanSyed Musthapa Meeran
Mar 25, 2008·Cancer Letters·Pranav K ChaturvediYogeshwer Shukla
Feb 6, 2009·International Journal of Cancer. Journal International Du Cancer·Joice Kuroiwa-TrzmielinaFernando Salvador Moreno
Jul 17, 2012·Cell Adhesion & Migration·James S HaleJustin D Lathia
Mar 28, 2012·Biochimica Et Biophysica Acta·T Harshani Peiris, Néstor J Oviedo
May 8, 2007·Progress in Biophysics and Molecular Biology·Michael Levin
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Deepika Soni, Abhinav Grover

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