The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma

The Journal of Clinical Endocrinology and Metabolism
Marco LosaPietro Mortini

Abstract

Single-session stereotactic radiotherapy (SR) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of SR in patients who had previously received maximal surgical debulking at our center. The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 through 2006. The study was performed at a university hospital. Eighty-three acromegalic patients, 52 women and 31 men, with a mean age of 42.6 +/- 1.2 yr, participated in the study. The median follow-up was 69 months (interquartile range 44-107 months). The patients were treated with SR for residual or recurrent GH-secreting adenoma. Normalization of age- and sex-adjusted IGF-I levels together with a basal GH level below 2.5 microg/liter without concomitant GH-suppressive drugs was the goal of therapy. Fifty patients (60.2%) reached the main outcome of the study. The rate of remission was 52.6% at 5 yr [95% confidence interval (CI) 40.6-64.6%]. Another 13 patients (15.7%), who were resistant to somatostatin analogs, were in remission after SR. Multivariate analysis showed that low basal GH and IGF-I levels were associated with a favorable outcome. No serious side effects occu...Continue Reading

References

Feb 1, 1990·Clinical Endocrinology·M D LittleyM L Sutton
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·A M LandoltG Wellis
Apr 20, 2000·The New England Journal of Medicine·P J TrainerR J Davis
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·G BarrandeJ Bertherat
Nov 18, 2000·Pituitary·I M Jackson, G Noren
Jul 27, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·UNKNOWN Scandinavian Workshop on the Treatment of Acromegaly
Nov 27, 2001·European Journal of Endocrinology·R CozziR Attanasio
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·S MelmedUNKNOWN Acromegaly Treatment Consensus Workshop Participants
Jan 10, 2003·Clinical Endocrinology·Catherine BeauregardOmar Serri
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Roberto AttanasioMaura Arosio
Sep 24, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David M CookUNKNOWN AACE Acromegaly Guidelines Task Force
Mar 11, 2005·European Journal of Endocrinology·Panagiotis NomikosRudolf Fahlbusch
May 14, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B GuttJ Schopohl
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Frédéric CastinettiThierry Brue
Aug 3, 2005·European Journal of Endocrinology·G M BesserA F Daly
Dec 3, 2005·European Journal of Endocrinology·S MelmedA Giustina
May 3, 2006·Clinical Endocrinology·Jana JezkováLadislav Pecen
Sep 4, 2007·European Journal of Endocrinology·Einar Osland Vik-MoMorten Lund-Johansen

❮ Previous
Next ❯

Citations

Jan 12, 2013·Pituitary·Thomas J WilsonStephen E Sullivan
Sep 3, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Brooke Swearingen, Jay Loeffler
Feb 24, 2010·Nature Reviews. Endocrinology·Frederic CastinettiThierry Brue
Jul 4, 2009·Journal of Veterinary Internal Medicine·R K SellonP R Gavin
Apr 21, 2012·International Journal of Endocrinology·Alberto FranzinPietro Mortini
Apr 21, 2012·International Journal of Endocrinology·Yvette MarquezGabriel Zada
Apr 21, 2012·International Journal of Endocrinology·John D Rolston, Lewis S Blevins
Dec 6, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Sep 27, 2012·Journal of Medical Case Reports·Seamus SreenanRichard Landau
Oct 5, 2010·Neurologia Medico-chirurgica·Tomoyuki KogaNobuhito Saito
Oct 5, 2010·Neurologia Medico-chirurgica·Koji KajiwaraMichiyasu Suzuki
Oct 5, 2010·Neurosurgical Focus·Nathan C Rowland, Manish K Aghi
Oct 5, 2010·Neurosurgical Focus·Isaac YangMarvin Bergsneider
Jun 26, 2012·Journal of Neurosurgery·Nicholas F MarkoRobert J Weil
Feb 6, 2010·European Journal of Endocrinology·S RougU Feldt-Rasmussen
Feb 9, 2011·European Journal of Endocrinology·Cristina L RonchiMaura Arosio
Mar 6, 2013·World Neurosurgery·Bruce E Pollock
Dec 19, 2008·Journal of Endocrinological Investigation·A GiustinaE Ghigo
Aug 5, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Syed Ali ImranDavid B Clarke
Jun 23, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Dec 5, 2008·Expert Opinion on Investigational Drugs·Jens BollerslevJens P Berg
Oct 23, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hiren PattNalini S Shah
Oct 9, 2012·Neurosurgery Clinics of North America·Jason P SheehanMark J Lobo
Aug 28, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G NoëlZ Jastaniah
Jun 19, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M-E Chand-FouchéP-Y Bondiau
Oct 18, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Fatih M ErdurPinar Kadioglu
Oct 29, 2008·La Presse médicale·Frédéric Castinetti, Thierry Brue
Jun 11, 2009·Clinical Endocrinology·Cristina L RonchiMaura Arosio
Jan 6, 2015·Pituitary·Kristopher T KimmellNicholas F Marko
Sep 28, 2014·Pituitary·Henry Ka-Fung MakMax Wintermark
Sep 10, 2014·International Journal of Radiation Oncology, Biology, Physics·Daniel A WattsonHelen A Shih
Jun 1, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gianluisa SicignanoRiccardo Calandrino
Apr 21, 2012·International Journal of Endocrinology·G MinnitiR Maurizi Enrici
Dec 2, 2014·Trends in Endocrinology and Metabolism : TEM·Gherardo MazziottiAndrea Giustina
Jan 15, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yoshiyasu IwaiKatsunobu Yoshioka
Oct 13, 2016·Radiation Oncology·Giuseppe MinnitiMaximillian Niyazi
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason P SheehanJay S Loeffler
Feb 9, 2018·Journal of Neuro-oncology·Mohana Rao PatibandlaJason P Sheehan
Oct 6, 2018·Clinical Endocrinology·Hugh P Sims-WilliamsJohn Newell-Price
Aug 17, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Mark J Winder, Marc R Mayberg
Sep 18, 2012·Radiation Oncology Journal·Chai Hong RimChul Yong Kim
Feb 21, 2014·The Journal of Clinical Endocrinology and Metabolism·Elena MalchiodiGiovanna Mantovani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Related Papers

European Journal of Endocrinology
Einar Osland Vik-MoMorten Lund-Johansen
The Journal of Clinical Endocrinology and Metabolism
Frédéric CastinettiThierry Brue
Journal of Neurosurgery
Jay JagannathanMary Lee Vance
© 2022 Meta ULC. All rights reserved