The role of steroids and their effects on phospholipase A2. An animal model of radiculopathy

Spine
H M LeeG F Gebhart

Abstract

The possible role of phospholipase A2 in an animal model for lumbar radiculopathy and mechanisms of epidural steroid injections were studied. To clarify the pathophysiologic mechanism of the recently proved animal model for lumbar radiculopathy and to characterize further the mechanisms of action of steroids. There have been several reported animal models of peripheral neuropathy. Recently an animal model that shows reliable behavioral and neurochemical changes was proposed, and epidural steroid injections in this model were effective in the reduction of thermal hyperalgesia and allodynia. In a behavioral study, 24 rats were divided into 4 groups: Group I, loose ligature of the left L4 and L5 nerve roots with 4-0 chromic gut sutures and an epidural injection of 0.1 mL of saline at 3 days after surgery; Group II, same as Group I but with an epidural injection of 0.1 mL of betamethasone on the day before the operation; Group II, same as Group II except injection at 1 day after surgery; Group IV, same as Group II except injection at 3 days after surgery. To test the phospholipase A2 activity in the nerve roots and dorsal root ganglia after the operation, eight rats were killed at given intervals. Analysis of variance techniques we...Continue Reading

References

Nov 1, 1977·Clinical Orthopaedics and Related Research·S D Gertzbein
Jun 1, 1992·Spine·R C FransonJ A Saal
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J D LevineE J Goetzl
Jan 1, 1969·Acta Orthopaedica Scandinavica·A Nachemson
Apr 1, 1973·The Journal of Experimental Medicine·J E Balow, A S Rosenthal
Jun 1, 1982·Clinical Rheumatology·J P Famaey
Mar 15, 1981·Experientia·S Pateromichelakis, J P Rood
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

❮ Previous
Next ❯

Citations

Jul 13, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Leif AnderbergHans Säveland
Jan 22, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Naresh Kumar, Veda Gowda
Jan 8, 2009·Current Pain and Headache Reports·Jai Sethee, James P Rathmell
Apr 20, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yishan LiuHong Zhang
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M KawakamiT Tamaki
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Stuart M WeinsteinUNKNOWN NASS
Jun 29, 2012·The Journal of Bone and Joint Surgery. American Volume·Kristen RadcliffJames N Weinstein
Oct 12, 2012·Journal of Pain Research·Laxmaiah ManchikantiRamsin Benyamin
Apr 24, 2013·World Journal of Orthopedics·Bao-Gan Peng
Aug 4, 2012·International Journal of Medical Sciences·Laxmaiah ManchikantiYogesh Malla
Jan 5, 2013·International Journal of Medical Sciences·Laxmaiah ManchikantiVidyasagar Pampati
Apr 17, 2014·International Journal of Pediatric Otorhinolaryngology·Chul Ho JangWon-Kyo Jung
Jan 9, 2014·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Gun Woo LeeJae-Do Kim
Nov 21, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jan FritzPhilippe L Pereira
Oct 8, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jae Hee Woo, Hahck Soo Park
Apr 6, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Chin-wern Chan, Philip Peng
May 13, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Prashant Chandrakant KambleVijay Khapane
Oct 23, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rahim MohammadiHesamaddin Eskafian
Nov 15, 2012·Journal of Pain and Symptom Management·Ørnulf PaulsenOla Dale
Feb 18, 2016·Stem Cells International·Jeffrey ZeckserJosh Goodwin
Jan 25, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Daniel LeungAnthony E Chiodo
Oct 7, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Mark PaidinRichard Kendall
Mar 8, 2003·Physical Medicine and Rehabilitation Clinics of North America·Venu AkuthotaGwendolyn Sowa
May 13, 2004·Regional Anesthesia and Pain Medicine·Noor M Gajraj
Feb 25, 2003·Techniques in Vascular and Interventional Radiology·Andrew L Wagner, F Reed Murtagh
May 29, 2004·American Journal of Physical Medicine & Rehabilitation·Curtis W SlipmanHoward B Jackson
Oct 1, 2011·American Journal of Physical Medicine & Rehabilitation·Ali ShakirBina Mehta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.