Mar 15, 2008

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

Nature Reviews. Microbiology
Aras KadiogluPeter W Andrew

Abstract

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an ability to evade the early components of the host immune response, this organism can spread from the upper respiratory tract to the sterile regions of the lower respiratory tract, which leads to pneumonia. In this Review, we describe how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease.

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References

Mentioned in this Paper

Nasopharyngeal Diseases
Immune Response
Mycoplasma pneumoniae
Pathogenicity
Respiratory Tract Structure
Nasopharynx
Pathogenic Organism
Entire Upper Respiratory Tract (Body Structure)
Upper Respiratory Tract
Entire Lower Respiratory Tract (Body Structure)

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