The role of stress concentration in calcified bicuspid aortic valve.

Journal of the Royal Society, Interface
Tongran QinWei Sun

Abstract

Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the aging population, and is now believed to be a slow, progressive, yet actively regulated process. The disease progression can be divided into two phases: initiation phase associated with lipid deposition and inflammation response, and the later propagation phase with active calcification growth. It has been hypothesized that elevated mechanical stress plays a major role in both phases of disease progression. In order to identify a direct link between leaflet stress and calcification development, we performed patient-specific finite-element (FE) analyses of six bicuspid aortic valves (BAV), where the leaflets, raphe and calcifications were all considered. The results showed that during the initiation phase, calcium buildup is likely to occur along the leaflet-root attachment curve (ATC), and the commissures, which are subject to the most drastic changes in stress during the cardiac cycle. During the propagation phase, the presence of calcification would lead to local stress concentration along its boundary, hence further calcification growth. Three patterns of calcification formation were identified on BAV leaflets: 'radial', which extended radi...Continue Reading

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Citations

May 27, 2021·Advanced Healthcare Materials·Hieu T BuiLakshmi Prasad Dasi
Jul 3, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Tongran QinWei Sun

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