The role of stromal cell heparan sulphate in regulating haemopoiesis

Leukemia & Lymphoma
Deirdre R Coombe

Abstract

Intimate contact between haemopoietic progenitor cells and elements of the bone marrow stroma is required for progenitor cell proliferation and differentiation. It is believed that the stroma provides particular niches for the development of haemopoietic cells of different lineages. Cytokines, stromal cell surface molecules and molecules of the stromal extracellular matrix all contribute to defining these microenvironmental niches. Data obtained using an in vitro model of haemopoiesis support the view that progenitor cell adhesion to stroma is mediated by multiple receptor-ligand interactions. The possibility of a tethering step, mediated by the engagement of stromal cell heparan sulphate with its ligands on the progenitor cells, preceding stable cell adhesion is discussed. The role of stromal cell heparan sulphate is likely to include cytokine presentation to progenitors as well as the tethering of progenitors to stroma. It is proposed that intracellular signals induced by progenitor cell adhesion to stroma act in association with cytokine induced signals to regulate progenitor cell proliferation and differentiation.

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Citations

Mar 17, 2001·Journal of Immunological Methods·C D GreenD A Lewin
Apr 27, 2000·Experimental Hematology·J M NelissenC G Figdor
Jul 16, 2008·Immunology and Cell Biology·Deirdre R Coombe
Sep 26, 2001·Transplantation·Q WangX Cao
Jan 23, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E D LitwackA D Lander
May 18, 2000·American Journal of Hematology·R TanejaD H Livingston
Mar 28, 2001·Annals of the New York Academy of Sciences·P GascónP Rameshwar

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