The role of strut chordae in mitral valve competence during annular dilation.

Perfusion
Samuel TaylorDaniel M Espino

Abstract

Strut chordae, on their own, are not typically thought to aid mitral valve competence. The aim of this study is to assess whether strut chordae aid mitral valve competence during acute annular dilation. Twelve porcine hearts were dissected and tested using an in vitro simulator, with the mitral annulus tested in either a 'normal' or a dilated configuration. The normal configuration included a diameter of 30 mm, a posterior leaflet 'radius' of 15 mm and a commissural corner 'radius' of 7.5 mm; the dilated annular template instead used dimensions of 50 mm, 25 mm and 12.5 mm, respectively. Each mitral valve underwent ten repeat tests with a target systolic pressure of 100 mmHg. No significant difference in the pressure was detected between the dilated and regular annuli for the mitral valves tested (95 ± 3 mmHg cf. 95 ± 2 mmHg). However, the volume of regurgitation for a dilated annulus was 28 ml greater than for a valve with a normal annulus. Following severing of strut chordae, there was a significant reduction in the systolic pressure withstood before regurgitation by mitral valves with dilated annuli (60 ± 29 mmHg cf. 95 ± 2 mmHg for normal annular dimensions; p < 0.05). In conclusion, strut chordae tendineae may play a role i...Continue Reading

References

Apr 1, 1996·The American Journal of Cardiology·M Tanimoto, R G Pai
Feb 13, 2001·The American Journal of Cardiology·E C JonesB V Howard
Jun 11, 2003·Circulation·Wolfgang A GoetzCarlos M G Duran
Mar 5, 2005·The Journal of Thoracic and Cardiovascular Surgery·Sten Lyager NielsenJ Michael Hasenkam
May 24, 2005·Medical Engineering & Physics·D M EspinoK Buchan
Jul 1, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Erwan DonalJean-Claude Daubert
May 23, 2012·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Mushtak Al-AtabiKeith G Buchan
Sep 18, 2013·The Journal of Thoracic and Cardiovascular Surgery·Antonio M CalafioreMichele Di Mauro
Dec 10, 2013·Journal of the Mechanical Behavior of Biomedical Materials·A G WilcoxD M Espino
Sep 27, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Vinayak BapatMartyn Thomas
Dec 4, 2014·Journal of Cardiovascular Computed Tomography·Philipp BlankeJonathon Leipsic
Dec 14, 2016·Cardiovascular Engineering and Technology·Hanna E BurtonDaniel M Espino
Jul 1, 2017·Micron : the International Research and Review Journal for Microscopy·Hanna E BurtonDaniel M Espino
Jan 1, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Saeed Adham EsfahaniDaniel M Espino
Feb 28, 2019·Applied Bionics and Biomechanics·Hanna E Burton, Daniel M Espino
Apr 4, 2020·Journal of Anatomy·Diana OliveiraDuncan Shepherd

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Citations

Nov 25, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Rhiannon NortheastDaniel M Espino

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