PMID: 7512932Feb 1, 1994Paper

The role of submucosal oedema in increased peripheral airway resistance by intravenous volume loading in dogs

The European Respiratory Journal
G J Tang, A N Freed

Abstract

Pulmonary congestion leads to an increase in airway resistance. It is still unknown whether this is due to vascular engorgement or to submucosal oedema. The present study was designed to determine the relative contribution of these two potential mechanisms. We examined the effect of intravenous volume loading on canine peripheral airway resistance (Rp). Bronchoscopes were wedged in contralateral sublobar segments and used to record Rp during rapid infusion of normal saline. Volume loading with normal saline increased pulmonary capillary wedge pressure (PCWP) and Rp. Unlike normal saline, dextran 70 did not increase Rp when infused at a rate that produced similar changes in PCWP. During infusion of normal saline, delta Rp was significantly enhanced in lung segments previously challenged with dry air when compared to contralateral control lungs, unexposed to dry air, and the use of dextran 70 significantly reduced this effect. Vasoconstriction with phenylephrine significantly decreased baseline Rp, but did not completely reverse the effect of fluid infusion. In addition, in lung segments exposed to dry air, delta Rp was significantly greater after volume loading and treatment with phenylephrine when compared to contralateral cont...Continue Reading

Citations

Jan 15, 2002·Respiration Physiology·Michael S DavisArthur N Freed
Sep 16, 2011·Respiratory Medicine·Jordan A GuenetteDenis E O'Donnell
Apr 4, 2003·Medicine and Science in Sports and Exercise·Michael S DavisArthur N Freed
Nov 27, 2009·Journal of Applied Physiology·Riccardo PellegrinoRaffaele Dellacà
May 6, 2003·Journal of Applied Physiology·Riccardo PellegrinoVito Brusasco

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