The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat.

Neuroscience
S M LouisG J Dockray

Abstract

Immunohistochemistry combined with retrograde tracing has been used to show that of the afferent neurons supplying the dorsomedial surface of the hind paw, approximately 30% contain substance P and 50% calcitonin gene-related peptide immunoreactivity. Stimulation of the saphenous nerve causes plasma extravasation and antidromic vasodilatation in this area of skin. The roles of calcitonin gene-related peptide and substance P released from peripheral afferent endings in mediating these effects were examined using immunoneutralization. In pilot experiments, the binding of radiolabelled peptide to the immunoglobulin fraction of calcitonin gene-related peptide and substance P antisera was characterized in quasi-physiological conditions. Systemic administration of either substance P or calcitonin gene-related peptide antibodies caused a significant decrease (P less than 0.05) in plasma extravasation measured by the Evans Blue method in response to topical application of mustard oil (0.5%) to the skin, or of capsaicin (5 microM) to the saphenous nerve. Topical application of mustard oil also produced a 52.9 +/- 5.1% increase in skin red cell flux. This increase was significantly decreased by both substance P and calcitonin gene-relate...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Jan 3, 1985·Nature·S D BrainI MacIntyre
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·N JancsóJ Szolcsányi
Oct 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Oberg
Nov 8, 1958·Nature·C C CURTAIN

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Citations

Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·N S DohertyA J Milici
Jan 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M DuxF K Pierau
Mar 10, 2011·Journal of Natural Medicines·Solomon Umukoro, Abimbola S Olugbemide
Mar 30, 2004·Autonomic Neuroscience : Basic & Clinical·Muriel LaraucheJean Fioramonti
Aug 27, 1997·European Journal of Pharmacology·H InoueY Koshihara
Apr 6, 1999·Pharmacology & Therapeutics·H Izumi
Apr 11, 2003·Neuroscience Letters·Ferenc DomokiGábor Jancsó
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C PothoulakisS E Leeman
Jun 30, 1992·Annals of the New York Academy of Sciences·G J DockrayR Dimaline
Jan 1, 1992·Annals of the New York Academy of Sciences·K A Sharkey
Jun 18, 1998·Annals of the New York Academy of Sciences·P G GreenJ D Levine
Aug 12, 2014·BioMed Research International·Massimo OrigoniMassimo Candiani

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