The role of surface microtopography in the modulation of osteoblast differentiation

European Cells & Materials
J S HayesRobert G Richards

Abstract

The osteoinductive and conductive capabilities of commercially pure titanium and its alloys is well documented, as is their ability to provide long-term stability for permanent implantable devices. Fracture fixation in paediatric and trauma patients generally requires transient fixation after which the implant becomes redundant and requires removal. Removal can be complicated due to excessive bony over-growth which is encouraged by the standard micro-rough implant surface. We have shown in vivo that removal related morbidity can be significantly reduced with surface polishing, a technique which reduces the micro-roughness of clinically available materials. However, tissue integration at the bone-implant interface requires activation of key regulatory pathways which influences osteoblastic differentiation and maturation therefore we do not believe this effect to be purely mechanical. To elucidate potential mechanisms by which surface polishing exerts its effect on bone regeneration this study assessed in vitro the effect of surface polishing commercially pure titanium on cell growth, morphology and on the regulation of core binding factor 1, osterix, collagen I, alkaline phosphatase, bone sialoprotein and osteocalcin for primary...Continue Reading

Citations

Nov 6, 2010·Expert Review of Medical Devices·J S Hayes, R G Richards
Dec 6, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·W MetzgerM Oberringer
Aug 24, 2012·Journal of Orthopaedic Trauma·R Geoff RichardsDavid W Grainger
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Mar 23, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·J S HayesR G Richards
Apr 18, 2018·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Shaun N RobertsonStuart Reid
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Apr 13, 2019·Dental Materials : Official Publication of the Academy of Dental Materials·A Llama-PalaciosD Herrera
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