The role of surgery and adjuvants to survival in Pagetic osteosarcoma.

Clinical Orthopaedics and Related Research
Pietro RuggieriMario Mercuri

Abstract

Osteosarcoma is a rare complication of Paget's disease with a very poor prognosis. Treatment is controversial: the older age of the patients affected by Paget's disease may limit the use of chemotherapy and axial involvement may limit the practicality of surgery. The purposes of this study are (1) to report the survival in patients treated for osteosarcoma in Paget's disease; (2) to identify correlations between type of treatment and survival comparing our data with those in the literature; (3) to determine if the extent of Paget's disease and risk of malignant transformation are associated; (4) to assess if prognosis is related with site; and (5) to identify the variations of histologic subtypes of these osteosarcomas. We retrospectively reviewed the medical records of 26 patients treated between 1961 and 2006 who had bone sarcoma arising from a site of Paget's disease. Twenty two of the 26 patients had surgery. In six surgery only was performed; three had surgery, adjuvant chemotherapy, and radiotherapy; one surgery and radiotherapy; 12 underwent surgery and chemotherapy, adjuvant in 10 patients and neoadjuvant in two; two had only radiotherapy and two had only chemotherapy. We performed survival analyses between various comb...Continue Reading

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Citations

Jan 31, 2017·La Revue de médecine interne·G JelinV Goëb
Feb 26, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stuart H RalstonStephen P Tuck
Oct 20, 2012·The Journal of Bone and Joint Surgery. American Volume·Joseph H SchwabFrancis J Hornicek
Jan 29, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Federica Scotto di CarloFernando Gianfrancesco
Aug 17, 2015·Veterinary Sciences·Timothy M Fan, Chand Khanna
Jan 3, 2021·Skeletal Radiology·William Tilden, Asif Saifuddin
Apr 22, 2021·Current Oncology Reports·Rebekah BelaynehKurt R Weiss

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