The role of surgical resection in Unicentric Castleman's disease: a systematic review

Advances in Respiratory Medicine
Sofoklis MitsosNikolaos Panagiotopoulos

Abstract

Castleman's disease is a rare benign lymphoproliferative disorder of unknown etiology. The disease occurs in two clinical forms with different prognoses, treatments and symptoms: a unicentric form (UCD), which is solitary, localized, and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. This article aims to review the current literature to consolidate the evidence surrounding the curative potential of surgical treatment to the unicentric type. A systematic review of English-language literature was performed and databases (Medline, Pubmed, the Cochrane Database and grey literature) were searched to identify articles pertaining to the treatment of unicentric form of Castleman's disease. Each article was critiqued by two authors using a structured appraisal tool, and stratified according to the level of evidence. After application of inclusion criteria, 14 studies were included. There were no prospective randomized control studies identified. One meta-analysis including 278 patients with UCD reported that resective surgery is safe and should be considered the gold standard for treatment. Seven retrospective studies enhance this standpoint. Radiotherapy (RT) has been used in six studies with co...Continue Reading

Citations

Aug 14, 2020·JAMA Otolaryngology-- Head & Neck Surgery·Bonnie ChenRod Rezaee
Apr 2, 2019·Advances in Anatomic Pathology·Ameer Hamza, Annikka Weissferdt
Feb 7, 2020·Acta chirurgica Belgica·Murat KaraGulcin Yegen
Jan 9, 2020·World Journal of Clinical Cases·Xiao-Yun XuJian-Hua Liu
Jul 1, 2021·Annals of Medicine and Surgery·Frans Serpa CarmomaEmilia Flores
Oct 1, 2021·Clinical Transplantation·Bingqing YueJingyu Chen

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Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

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