The role of survivin on overall survival of non-small cell lung cancer, a meta-analysis of published literatures

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Jiang FanJia-An Ding

Abstract

The prognostic value of survivin for survival of patients with non-small cell lung cancer (NSCLC) remains controversial. The authors performed a meta-analysis of the literatures in order to clarify its impact. Published studies were identified using an electronic search in order to aggregate the available survival results. To be eligible, a study had to have dealt with survivin assessment in NSCLC patients on the primary site and have analyzed survival according to survivin expression. There were 10 eligible studies and data from eight studies where non-location specific immunohistochemistry (IHC) definition system, in situ hybridization (ISH) and RT-PCR used were combined to present the impact of survivin on overall survival (OS) of NSCLC. The level of survivin expression correlated with the OS of NSCLC patients significant (RR 1.88, 95% CI 1.31-2.70, P=0.0006). Data of seven studies were combined to demonstrate that the level of survivin correlated with the OS of NSCLC patients who had received radical surgeries (RR 1.79, 95% CI 1.45-2.20, P<0.00001). Data from three studies were combined to find that the level of nuclear survivin did not have impact on OS of NSCLC patients (RR 1.58, 95% CI 0.87-2.85, P=0.13). Positive-surviv...Continue Reading

References

Jan 2, 2003·Nature Reviews. Cancer·Dario C Altieri
Aug 5, 2003·The Journal of Pathology·Monica FalleniSilvano Bosari
Sep 26, 2003·Seminars in Surgical Oncology·Mitchell Machtay, Branislav Jeremic
Jun 29, 2004·Seminars in Cancer Biology·Boaz NachmiasDina Ben-Yehuda
Jul 22, 2004·British Journal of Cancer·B LuD E Hallahan
Nov 3, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B VischioniG Giaccone
May 3, 2006·Respiratory Medicine·Sükran AtikcanAydin Yilmaz
Jul 1, 2006·Virchows Archiv : an International Journal of Pathology·Nalan AkyürekCan Oztürk
Nov 24, 2006·Molecular Cancer Therapeutics·Barbara VischioniGiuseppe Giaccone

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Citations

Sep 10, 2011·Therapeutic Advances in Medical Oncology·Thierry BerghmansJean-Paul Sculier
Jan 1, 2009·Folia Histochemica Et Cytobiologica·Wojciech NaumnikElzbieta Chyczewska
Feb 18, 2014·International Journal of Molecular Sciences·Mahsa MobahatKarl Riabowol
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hai-Hua QianHai-Xia Guo
Aug 19, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ping ZhanYong Song
Oct 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Juncheng DaiHongbing Shen
Jan 29, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anjaiah SrirangamDavid A Potter
Apr 22, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Haifeng XiaHaitao Ma
Dec 12, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Antonio RosatoAmbrogio Fassina
Oct 27, 2010·Cancer Letters·Milind M PoreFrank A E Kruyt
Apr 22, 2009·Cancer Letters·Vaios KaranikasAnastasios E Germenis
Jul 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shang-mian YieEn Gao
Jul 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Bin WangYi Han
Feb 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jamsheed JavidAlpana Saxena
Oct 25, 2011·International Immunopharmacology·Meltem BaykaraSuleyman Buyukberber
Apr 17, 2013·Journal of the Egyptian National Cancer Institute·Amal FawzyMahmoud Eldeib
Feb 21, 2009·Journal of Experimental & Clinical Cancer Research : CR·Shin-ichi YamashitaKatsunobu Kawahara
Apr 24, 2013·Asian Pacific Journal of Tropical Medicine·Xiao-Wei LiuLi-Feng Sun
Jan 16, 2013·Asian Pacific Journal of Tropical Medicine·Xiao-Yu LuHai Huang
Sep 18, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Lan XieJing Wang
Oct 27, 2017·Apoptosis : an International Journal on Programmed Cell Death·Mervat S MohamedAyat G Ali
Aug 3, 2013·Virchows Archiv : an International Journal of Pathology·Ping-Li SunJin-Haeng Chung
Aug 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Teresa EzpondaLuis M Montuenga

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