PMID: 6989754Jan 1, 1980Paper

The role of sympathetic activity in normal renin essential hypertension

Hypertension
F W EngD S McCann

Abstract

Understanding the connection between sympathetic activity and essential hypertension is still rudimentary. We studied interrelationships of plasma catecholamines, plasma renin activity (PRA), aldosterone, sodium intake, and therapeutic response of 20 normal renin hypertensives. Based on plasma norepinephrine (NE), this population fell into two distinct subsets. The 11 patients in the "normal" NE subset had a basal NE of 257 +/- 49 pg/ml (vs 250 +/- 62 pg/ml in normotensives), while nine patients in the "high" range NE group averaged 522 +/- 125 pg/ml. Both NE subsets showed significant correlation between mean arterial pressure (MAP) and NE. Only the "normal" NE subset showed significant correlation between MAP and PRA, and MAP and aldosterone. Correlations between changes in Na+ excretion and NE, PRA, and aldosterone were all negative and statistically significant. Blood pressure was controlled in eight of 11 "normal" NE patients but only in one of nine "high" NE patients by restriction of Na+ intake and/or use of a diuretic.

References

Nov 1, 1977·Clinics in Endocrinology and Metabolism·J de Champlain
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M S RomoffS G Massry
Jan 27, 1977·The New England Journal of Medicine·C R LakeI J Kopin
Feb 24, 1977·The New England Journal of Medicine·M EslerV DeQuattro
Sep 1, 1977·American Journal of Obstetrics and Gynecology·R P LedermanM J Huber
Dec 2, 1976·The New England Journal of Medicine·H GavrasH R Brunner
Nov 23, 1976·The American Journal of Cardiology·V DeQuattroD J Meijer
Feb 1, 1976·Circulation Research·J de ChamplainM R van Ameringen
Mar 2, 1972·The New England Journal of Medicine·H R BrunnerF R Bühler
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
Sep 1, 1973·The American Journal of Medicine·V DeQuattro, Y Miura
Oct 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·M S Christensen, N J Christensen
Mar 22, 1973·The New England Journal of Medicine·W J LouisS Anavekar
Mar 1, 1961·The Journal of Clinical Endocrinology and Metabolism·A GOLDFIENG W THORN

❮ Previous
Next ❯

Citations

Jan 1, 1981·Clinical and Experimental Hypertension : CHE·J de ChamplainG Denis
Mar 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A GangulyN S Fineberg
Dec 1, 1982·American Heart Journal·R P SorkinD S McCann
Nov 1, 1983·Hypertension·P A BridleC M Ferrario
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.