Abstract
Understanding the connection between sympathetic activity and essential hypertension is still rudimentary. We studied interrelationships of plasma catecholamines, plasma renin activity (PRA), aldosterone, sodium intake, and therapeutic response of 20 normal renin hypertensives. Based on plasma norepinephrine (NE), this population fell into two distinct subsets. The 11 patients in the "normal" NE subset had a basal NE of 257 +/- 49 pg/ml (vs 250 +/- 62 pg/ml in normotensives), while nine patients in the "high" range NE group averaged 522 +/- 125 pg/ml. Both NE subsets showed significant correlation between mean arterial pressure (MAP) and NE. Only the "normal" NE subset showed significant correlation between MAP and PRA, and MAP and aldosterone. Correlations between changes in Na+ excretion and NE, PRA, and aldosterone were all negative and statistically significant. Blood pressure was controlled in eight of 11 "normal" NE patients but only in one of nine "high" NE patients by restriction of Na+ intake and/or use of a diuretic.
References
Nov 1, 1977·Clinics in Endocrinology and Metabolism·J de Champlain
Jul 17, 1976·Lancet·M EslerP Rydelek
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M S RomoffS G Massry
Jun 18, 1976·Science·R R MichaelsD S McCann
Jan 27, 1977·The New England Journal of Medicine·C R LakeI J Kopin
Feb 24, 1977·The New England Journal of Medicine·M EslerV DeQuattro
Feb 1, 1977·The American Journal of Medicine·P WeidmannW H Ziegler
Sep 1, 1977·American Journal of Obstetrics and Gynecology·R P LedermanM J Huber
Jun 1, 1976·Life Sciences·C R LakeI J Kopin
Dec 2, 1976·The New England Journal of Medicine·H GavrasH R Brunner
Nov 23, 1976·The American Journal of Cardiology·V DeQuattroD J Meijer
Nov 1, 1975·Acta Medica Scandinavica·E B Pedersen, N J Christensen
Feb 1, 1976·Circulation Research·J de ChamplainM R van Ameringen
Mar 2, 1972·The New England Journal of Medicine·H R BrunnerF R Bühler
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
Sep 1, 1973·The American Journal of Medicine·V DeQuattro, Y Miura
Oct 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·M S Christensen, N J Christensen
Mar 22, 1973·The New England Journal of Medicine·W J LouisS Anavekar
Mar 1, 1961·The Journal of Clinical Endocrinology and Metabolism·A GOLDFIENG W THORN
Citations
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·E Degli EspostiP Zucchelli
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·J de ChamplainG Denis
Mar 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A GangulyN S Fineberg
Dec 1, 1982·American Heart Journal·R P SorkinD S McCann
Jan 1, 1983·Hypertension·D S Goldstein
Sep 1, 1981·Hypertension·D S Goldstein
Jul 1, 1985·Circulation·M VolpeB Trimarco
Aug 1, 1992·Hypertension·S FrontoniL Rossetti
Nov 1, 1983·Hypertension·P A BridleC M Ferrario
Jan 1, 1981·Hypertension·D S Goldstein
May 1, 1984·Hypertension·K MasuoH Wada
Sep 1, 1983·Hypertension·K MasuoH Wada
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich