The role of syncytia during viral infections.

Journal of Theoretical Biology
Benjamin Jessie, Hana M Dobrovolny

Abstract

Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract. RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together. We use a mathematical model to study how different assumptions about the viral production and lifespan of syncytia change the resulting infection time course. We find that the effect of syncytia on viral titer is only apparent when the basic reproduction number for infection via syncytia formation is similar to the reproduction number for cell free viral transmission. When syncytia fusion rate is high, we find the presence of syncytia can lead to slowly growing infections if viral production is suppressed in syncytia. Our model provides insight into how the presence of syncytia can affect the time course of a viral infection.

References

Oct 20, 2000·The Journal of General Virology·I Martínez, J A Melero
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·L González-ReyesJ A Melero
Jan 15, 2004·The Journal of Infectious Diseases·Edward E WalshAnn R Falsey
Jul 15, 2006·Journal of Virology·Prasith BaccamAlan S Perelson
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hannah Yuan ChenLinqi Zhang
Jul 28, 2009·Journal of Mathematical Biology·Amber M SmithAlan S Perelson
Dec 3, 2010·PloS One·Hana M DobrovolnyCatherine A A Beauchemin
Feb 6, 2013·The Journal of Infectious Diseases·Edward E WalshAnn R Falsey
Mar 10, 2015·Mathematical Biosciences·Karly Jacobsen, Sergei S Pilyugin
Oct 10, 2015·Computational and Mathematical Methods in Medicine·Gilberto González-Parra, Hana M Dobrovolny
Dec 3, 2016·Vaccine·Geraldine Taylor
Sep 5, 2017·Intervirology·Talita Bianca GagliardiEurico Arruda
Jul 27, 2018·Journal of Theoretical Biology·Gilberto González-Parra, Hana M Dobrovolny
Aug 26, 2018·Virology·Gilberto González-Parra, Hana M Dobrovolny
Mar 8, 2019·Virus Research·Nicolás Cifuentes-Muñoz, Rebecca Ellis Dutch
Apr 24, 2019·Journal of Mathematical Biology·Gilberto González-Parra, Hana M Dobrovolny
Jun 4, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Steven J DrewsNelson Lee
Aug 4, 2019·Journal of Virology·Julia R DillerKristen M Ogden
Sep 16, 2019·The Journal of Infection·Laura ToivonenVille Peltola
Nov 2, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Abraham AliDiogo Ribeiro
Feb 14, 2020·Epidemiology and Infection·M Tin Tin HtarD L Swerdlow
May 4, 2020·Journal of Infection and Public Health·Fatima SalehHassan Zaraket
May 30, 2020·International Reviews of Immunology·Rauf BhatFahad N Almajhdi
Jun 20, 2020·Cellular and Molecular Life Sciences : CMLS·C EfstathiouN J Stevenson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.