The role of T cells in the microenvironment of Hodgkin lymphoma

Journal of Leukocyte Biology
Frederik Wein, Ralf Küppers

Abstract

The cellular microenvironment in HL is dominated by a mixed infiltrate of inflammatory cells with typically only 1 or a few percent of HRS tumor cells. HRS cells orchestrate this infiltrate by the secretion of a multitude of chemokines. T cells are usually the largest population of cells in the HL tissue, encompassing Th cells, T(regs), and CTLs. Th cells and T(regs) presumably provide essential survival signals for the HRS cells, and the T(regs) also play an important role in rescuing HRS cells from an attack by CTLs and NK cells. The interference with this complex interplay of HRS cells with other immune cells in the microenvironment may provide novel strategies for targeted immunotherapies.

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Citations

Nov 13, 2018·British Journal of Haematology·Melita CirilloSven Borchmann
May 17, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ya-Ping ZhangJian-Yong Li
May 21, 2019·Therapeutic Advances in Hematology·Nicole A Carreau, Catherine S Diefenbach
Jun 20, 2018·Frontiers in Oncology·Christoph Renner, Frank Stenner
Nov 7, 2019·International Journal of Molecular Sciences·Eleonora CalabrettaCarmelo Carlo-Stella
Apr 17, 2020·Frontiers in Immunology·Hinrich P HansenMichael Hallek
Oct 27, 2017·Cancer Immunology Research·Frederik WeinRalf Küppers
Mar 10, 2021·Leukemia·Marc A Weniger, Ralf Küppers
Apr 4, 2021·International Journal of Molecular Sciences·Clifford M Csizmar, Stephen M Ansell

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