PMID: 9178073Jan 1, 1997Paper

The role of T cells in the regulation of B cell tolerance

International Reviews of Immunology
B Fazekas de St GrothA L Smith

Abstract

The study of conventional models of B cell tolerance has suggested that self-tolerance is imposed on B cells at an early stage in their development due to a peculiar sensitivity of immature B cells to tolerance induction. While this concept accounts for some aspects of central B cell tolerance, it is inconsistent with recent reports of tolerance induction in mature splenic B cells from immunoglobulin transgenic mice. We present an alternative model, the hierarchical model (Aust. N. Z. J. Med. 25, 761-767, 1995), in which regulation of naive B cell reactivity is a function of antigen signal strength and availability of T cell help, but is independent of B cell maturation stage. In turn, the development of tolerance or memory in the T cell compartment is dependent on a combination of antigen-MHC recognition by T cells and antigen-nonspecific signalling by antigen-presenting cells. Using a transgenic model of T-B collaboration, we have shown that both immature and mature self-reactive B cells can be rescued and induced to secrete auto-antibody if the B cell determinant is linked to a carrier protein bearing a foreign T cell determinant.

References

Feb 1, 1975·The Australian Journal of Experimental Biology and Medical Science·K J Lafferty, A J Cunningham
Jan 1, 1977·The Journal of Experimental Medicine·D PrimiG Möller
Jan 1, 1979·Immunological Reviews·E S MetcalfN R Klinman
Jan 1, 1979·Immunological Reviews·G J NossalF L Battye
Jan 1, 1979·Immunological Reviews·D W ScottJ J Jandinski
Sep 1, 1977·The Journal of Experimental Medicine·D E TrenthamA H Kang
Nov 13, 1992·Science·E J Fuchs, P Matzinger
Aug 8, 1991·Nature·C C GoodnowE Adams
Aug 1, 1991·Immunological Reviews·A BastenC C Goodnow
Jan 1, 1986·Advances in Immunology·R H Schwartz
May 15, 1988·Hospital Practice·M M Davis
Jul 1, 1986·The Journal of Experimental Medicine·D PortnoïA Coutinho
Jan 1, 1973·Advances in Immunology·W O Weigle
Sep 11, 1970·Science·P Bretscher, M Cohn
Jan 1, 1983·Annual Review of Immunology·G J Nossal
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G J Nossal, B L Pike
Nov 1, 1980·The Journal of Clinical Investigation·D E TrenthamJ R David
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M ErisP D Hodgkin
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Feb 1, 1995·Current Opinion in Immunology·P D Hodgkin, A Basten
Jan 1, 1994·Autoimmunity·D A Fulcher, A Basten
Mar 1, 1994·European Journal of Immunology·U SteinhoffR Zinkernagel
May 1, 1994·The Journal of Experimental Medicine·W Y HoM M Davis
Jan 1, 1994·Annual Review of Immunology·P Matzinger
May 2, 1994·Journal of Immunological Methods·A B Lyons, C R Parish
Jan 1, 1994·The Journal of Experimental Medicine·D A Fulcher, A Basten

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Citations

Dec 23, 1998·European Journal of Immunology·M C CookB Fazekas de St Groth
Nov 26, 1999·Immunology and Cell Biology·B Fazekas de St GrothP Bertolino
Mar 14, 2002·International Reviews of Immunology·M E MeloD W Scott
Aug 26, 1998·European Journal of Immunology·M C CookB Fazekas de St Groth

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