The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs

British Journal of Pharmacology
A LecciC A Maggi

Abstract

1. The role of endogenous tachykinins on guinea-pig colonic propulsion was investigated by using potent and selective tachykinin NK1 and NK2 receptor antagonists. Colonic propulsion and contractions were determined by means of a balloon-catheter device, inserted into the rectum of guanethidine (68 micromol kg(-1), s.c., 18 and 2 h before)-pretreated, urethane-anaesthetized guinea-pigs. Propulsion of the device (dynamic model) was determined by measuring the length of the catheter expelled during 60 min filling of the balloon (flow rate 5 microl min(-1)). 2. In control conditions the tachykinin NK1 receptor antagonist SR 140333 (1 micromol kg(-1), i.v.) did not affect either colonic propulsion or the amplitude of contractions. The tachykinin NK2 receptor antagonists MEN 10627 and MEN 11420 (1 micromol kg(-1), i.v.) increased colonic propulsion at 10 min (+120% and 150%, respectively) but at 60 min the effect was significant only for MEN 10627 (+84%). SR 48968 (1 micromol kg(-1), i.v.) did not significantly enhance the colonic propulsion. None of these tachykinin NK2 receptor antagonists modified the amplitude of colonic contractions. In contrast, both atropine (6 micromol kg(-1), i.v., plus infusion of 1.8 micromol h(-1)) and he...Continue Reading

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Citations

Nov 8, 2001·European Journal of Pharmacology·R Patacchini, C A Maggi
Oct 7, 2006·Current Opinion in Gastroenterology·J R Grider, A E Foxx-Orenstein
May 11, 2002·Archives of Histology and Cytology·Ichiro TakayamaShinichi Ohno
Mar 24, 2004·British Journal of Pharmacology·Alessandro LecciCarlo Alberto Maggi
Sep 30, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F MulèR Serio
Jul 5, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Y YuanS J Brookes
Aug 5, 2005·Journal of Pharmacological Sciences·Shiho OkanoNobuhiro Inatomi
Oct 12, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·T C SiaN J Spencer
Jun 1, 2013·Biomolecular Concepts·Maria Giuliana Vannucchi, Stefano Evangelista
Dec 22, 1999·The American Journal of Physiology·R SabanP J Pasricha
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L OnoriM Tonini
Aug 8, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CostaP G Dinning
Mar 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Luciano OnoriMarcello Tonini
Oct 26, 2000·Neuropeptides·A LecciC A Maggi

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