The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines

Cancer Letters
Myung-Jin KimPil-Young Yun

Abstract

The purpose of this study was to evaluate the effect of tamoxifen (TAM) when used in combination with cisplatin on oral squamous cell carcinoma (OSCC). For this, the relation between estrogen receptor (ER) expression level and the cytotoxic effect of TAM, the apoptotic effect and its molecular mechanisms of TAM were investigated using OSCC cell lines. Combination treatment demonstrated a superior cytotoxic and apoptotic effect on OSCC cell lines. Considerable amount of ER was detected in some OSCC cell lines, but there were no significant differences of cytotoxic effect of TAM. TAM inhibited PKC activity and up-regulated TGF-beta1 secretion.

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Citations

Jun 12, 2010·Molecular Cancer·Rajakishore Mishra
Feb 7, 2009·European Journal of Oral Sciences·Lu JiangQianming Chen
Jan 3, 2015·Biochimica Et Biophysica Acta·Joana Balça-SilvaMaria Celeste Lopes
Sep 27, 2013·Acta Odontologica Scandinavica·Luciana Sassa MarocchioSuzana O Machado de Sousa
Oct 29, 2013·Chemico-biological Interactions·Li-Yuan BaiChang-Fang Chiu
Sep 16, 2010·BMC Complementary and Alternative Medicine·Abdulmlik A GhashmRajan Saini

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