The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis

Neurochemical Research
Todd M Foos, Jang-Yen Wu

Abstract

The effects of taurine in the mammalian nervous system are numerous and varied. There has been great difficulty in determining the specific targets of taurine action. The authors present a review of accepted taurine action and highlight recent discoveries regarding taurine and calcium homeostasis in neurons. In general there is a consensus that taurine is a powerful agent in regulating and reducing the intracellular calcium levels in neurons. After prolonged L-glutamate stimulation, neurons lose the ability to effectively regulate intracellular calcium. This condition can lead to acute swelling and lysis of the cell, or culminate in apoptosis. Under these conditions, significant amounts of taurine (mM range) are released from the excited neuron. This extracellular taurine acts to slow the influx of calcium into the cytosol through both transmembrane ion transporters and intracellular storage pools. Two specific targets of taurine action are discussed: Na(+)-Ca2+ exchangers, and metabotropic receptors mediating phospholipase-C.

Citations

Aug 3, 2005·Cellular and Molecular Neurobiology·A N ChepkovaH L Haas
Apr 3, 2008·Microbiology and Immunology·Hiroko KitayamaYoshio Koyanagi
Apr 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hun-Taek KimPaul K Y Wong
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Katherine A BorkovichRobert Pratt
Aug 17, 2011·The Journal of General Physiology·Darren LockeAndrew L Harris
Apr 29, 2014·CNS Neuroscience & Therapeutics·Irene BoleaLaura Della Corte
Dec 30, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shunji ShiohiraKen Tsuchiya
Nov 3, 2017·Biological & Pharmaceutical Bulletin·Hyung Joo SuhKi-Bae Hong
Aug 20, 2010·Journal of the Science of Food and Agriculture·Fu-Rong WangQi Zhang
May 1, 2009·Diabetes/metabolism Research and Reviews·Rosane A RibeiroEverardo M Carneiro
May 20, 2017·Chemical Communications : Chem Comm·Enming DuYe Zhang
Oct 7, 2018·Journal of Neurovirology·Ameer AbutalebEleanor Wilson
Aug 13, 2003·Journal of Neurochemistry·Ramendra N Saha, Kalipada Pahan
Aug 24, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Hai-Bo YeShan-Kai Yin
Jan 1, 2013·Brain Sciences·Janet MenzieJang-Yen Wu
Feb 26, 2016·Nutritional Neuroscience·Xiang-Wen LiJing Liu
Sep 10, 2014·Neuroreport·Kristen RakRudolf Hagen
Nov 26, 2014·Molecular Neurobiology·Lance M VilleneuveHoward S Fox
Aug 21, 2012·Amino Acids·Janet MenzieJang-Yen Wu
Sep 17, 2017·Neuroscience and Biobehavioral Reviews·Nathana J MezzomoDenis B Rosemberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Essays in Neurochemistry and Neuropharmacology
G G Collins
Advances in Experimental Medicine and Biology
John B Lombardini
Advances in Experimental Medicine and Biology
T SegawaY Nomura
Progress in Clinical and Biological Research
H Pasantes-MoralesA Schousboe
© 2022 Meta ULC. All rights reserved