The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis

Oncogene
J M ParkR J Weigel

Abstract

TFAP2C/AP-2γ influences development of the mammary gland and regulates patterns of gene expression in luminal and HER2-amplified breast cancer. The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to cancer progression remain poorly understood. To gain greater insight into oncogenic mechanisms regulated by TFAP2C, we examined mammary tumorigenesis in MMTV-Neu transgenic female mice with or without conditional knockout (KO) of Tcfap2c, the mouse homolog of TFAP2C. Loss of Tcfap2c increased the latency of tumorigenesis and tumors that formed demonstrated reduced proliferative index and increased apoptosis. In addition, tumors formed in Tcfap2c KO animals had a significant reduction in Egfr levels without a change in the expression of the Neu oncogene. The MMneu-flAP2C cell line was established from tumor tissue derived from MMTV-Neu/Tcfap2c(L/L) control animals and parallel cell lines with and without expression of Tcfap2c were created by transduction with adenovirus-empty and adenovirus-Cre, respectively. KO of Tcfap2c in vitro reduced activated phosphorylated-Erk, decreased cell viability, repressed tumor growth and was associated with attenuation of Egfr expression. Chromatin immunoprecipitation and dire...Continue Reading

References

Mar 5, 1999·Breast Cancer Research and Treatment·M D PegramD J Slamon
Aug 30, 2000·Nature·C M PerouD Botstein
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jun 16, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J PellikainenV-M Kosma
Apr 15, 2005·Breast Cancer Research and Treatment·Richard JägerHubert Schorle
Feb 2, 2006·The Journal of Cell Biology·Xuan WangElaine Fuchs
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Nov 7, 2006·Trends in Cell Biology·Bryan Linggi, Graham Carpenter
Oct 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yago NietoSamia Nawaz
Feb 20, 2008·Neoplasia : an International Journal for Oncology Research·Shixia HuangYi Li
Jan 20, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B CorkeryN O'Donovan
Feb 5, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Richard JägerHubert Schorle
Jul 16, 2010·Genes, Chromosomes & Cancer·George W WoodfieldRonald J Weigel
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Nov 16, 2011·Current Molecular Medicine·F BertucciD Birnbaum
Dec 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Justin M BalkoRebecca S Cook
Oct 18, 2012·Breast Cancer Research and Treatment·Hiroko MasudaNaoto T Ueno
Apr 23, 2013·Nature Cell Biology·Sanja ŠaleSpyros Artavanis-Tsakonas
May 20, 2014·Cancer Cell·Maria V BogachekRonald J Weigel

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Citations

Mar 8, 2016·Critical Reviews in Oncology/hematology·Jean Piechowski
Feb 16, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin KleinFrank Stubenrauch
Feb 3, 2016·Molecular Cancer Therapeutics·James P De AndradeRonald J Weigel

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