The role of telavancin in hospital-acquired pneumonia and ventilator-associated pneumonia

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Christian E Sandrock, Andrew F Shorr

Abstract

Hospital-acquired pneumonia (HAP) due to gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major cause of morbid conditions and death. Telavancin is a lipoglycopeptide antibiotic with potent in vitro activity against a range of gram-positive pathogens, including MRSA, methicillin-susceptible S. aureus, and Streptococcus species. In 2 phase 3 clinical trials, telavancin was noninferior to vancomycin in patients with HAP due to gram-positive pathogens. Clinically evaluable patients with S. aureus as the sole pathogen or S. aureus with a vancomycin minimum inhibitory concentration >1 µg/mL, however, had higher cure rates with telavancin than with vancomycin. In patients with bacteremic HAP, telavancin resulted in clearance of blood cultures. It was associated with increased serum creatinine levels and higher mortality rates in patients with moderate to severe renal impairment at baseline; however, on subsequent analysis, the outcomes seemed to have been at least partially affected by the adequacy of empiric gram-negative antimicrobial therapy. Thus, clinicians need to consider the risk-benefit balance when choosing telavancin in patients with severe renal impairment at baseline. O...Continue Reading

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Citations

Sep 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric Wenzler, Keith A Rodvold
Sep 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Keith A Rodvold
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Sep 12, 2017·Expert Review of Respiratory Medicine·Katherine L RobertsMarin H Kollef
Feb 28, 2019·Frontiers in Pharmacology·Chao-Yang WangXue-Qun Ren
Nov 7, 2019·Drugs -- Real World Outcomes·Adam M BresslerBibiana Castaneda-Ruiz

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