The role of temozolomide in the treatment of aggressive pituitary tumors

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
James K LiuJean Anderson Eloy

Abstract

Pituitary tumors are amongst the most common intracranial neoplasms and are generally benign. However, some pituitary tumors exhibit clinically aggressive behavior that is characterized by tumor recurrence and continued progression despite repeated treatments with conventional surgical, radiation and medical therapies. More recently, temozolomide, a second generation oral alkylating agent, has shown therapeutic promise for aggressive pituitary adenomas and carcinomas with favorable clinical and radiographic responses. Temozolomide causes DNA damage by methylation of the O(6) position of guanine, which results in potent cytotoxic DNA adducts and consequently, tumor cell apoptosis. The degree of MGMT expression appears to be inversely related to therapeutic responsiveness to temozolomide with a significant number of temozolomide-sensitive pituitary tumors exhibiting low MGMT expression. The presence of high MGMT expression appears to mitigate the effectiveness of temozolomide and this has been used as a marker in several studies to predict the efficacy of temozolomide. Recent evidence also suggests that mutations in mismatch repair proteins such as MSH6 could render pituitary tumors resistant to temozolomide. In this article, the...Continue Reading

References

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Brennand, G P Margison
Feb 15, 1997·Cancer·P J PerniconeW C Schoene
Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Nov 5, 2002·Nature Reviews. Cancer·Sylvia L Asa, Shereen Ezzat
Jun 12, 2004·Neurosurgical Focus·Brian T Ragel, William T Couldwell
Jun 6, 2006·The Lancet Oncology·Stephen LimAnthony P Heaney
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian F PollackJonathan L Finlay
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel P CahillDavid N Louis
Oct 11, 2007·Acta Neuropathologica·Kalman KovacsLuis C Penagos
Apr 8, 2009·Neurosurgery·Safraz MohammedMichael D Cusimano
Jun 23, 2009·Cancer Chemotherapy and Pharmacology·J Lee VillanoLinda R Bressler
Jan 5, 2010·Hormones : International Journal of Endocrinology and Metabolism·Luis V SyroKalman Kovacs
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Gérald RaverotThierry Brue
Aug 27, 2010·Pituitary·Queenie LauRicardo Lloyd
Sep 17, 2010·Cancer·Luis V SyroEva Horvath
Mar 26, 2011·Expert Opinion on Pharmacotherapy·Annamaria ColaoGaetano Lombardi
Apr 19, 2011·European Journal of Clinical Investigation·Ann I McCormackAshley B Grossman
Jul 5, 2011·Hormones : International Journal of Endocrinology and Metabolism·Olga MoshkinKalman Kovacs
Aug 2, 2011·Pituitary·Bernd W ScheithauerK Kovacs
Sep 16, 2011·Pituitary·Leon D OrtizKalman Kovacs
Nov 16, 2011·World Neurosurgery·Ivan S Ciric
Nov 30, 2011·Current Molecular Pharmacology·Jihong ZhangTracey D Bradshaw
Feb 16, 2012·The Journal of Spinal Cord Medicine·Paul M ArnoldPhilip L Johnson
Mar 1, 2012·Clinical Endocrinology·B C WhitelawS J B Aylwin
Apr 24, 2012·Annales d'endocrinologie·Melanie PhilipponFrédéric Castinetti
May 25, 2012·Clinics·Leon D OrtizKalman Kovacs
Jul 17, 2012·Pituitary·Ann McCormackRoderick Clifton-Bligh
Oct 17, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Ayca ErsenKalman Kovacs
Oct 24, 2012·Case Reports in Endocrinology·Haruko MorokumaAtsushi Kawakami
Feb 21, 2013·Hormones : International Journal of Endocrinology and Metabolism·Jana PhillipsChristian A Koch
Mar 13, 2013·Cancer Investigation·Marie BatisseIgor Tauveron
Apr 9, 2013·International Journal of Cancer. Journal International Du Cancer·Congxin DaiRenzhi Wang
Aug 21, 2013·Medical Molecular Morphology·Akira MatsunoR Yoshiyuki Osamura

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Citations

Dec 25, 2015·The Journal of Endocrinology·M Victoria RecouvreuxGraciela Díaz-Torga
Aug 6, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Anni WongJames K Liu
Apr 18, 2016·Journal of Endocrinological Investigation·A G Ambrogio, F Cavagnini
Nov 29, 2016·Medicine·Zijiang YangHeng Gao
Apr 28, 2020·Journal of the Science of Food and Agriculture·Muhammad T AsgharYanty N Manaf
Mar 25, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·G L KobyakovP L Kalinin
Mar 12, 2017·Endocrine Pathology·Nicola TuftonMárta Korbonits
Jun 9, 2018·Frontiers in Endocrinology·Mariana FuertesEduardo Arzt
Jul 20, 2019·Case Reports in Neurology·Juliana Pérez PinzónEnrique Jiménez Hakim

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