The role of TERT promoter mutations in postoperative and preoperative diagnosis and prognosis in thyroid cancer

Medicine
Anqi JinYan Wang

Abstract

Telomerase reverse transcriptase (TERT) promoter mutations have been described in different pathological types of thyroid cancers (TC). After many types of research focusing on the mutations rate in malignant tumors, the main role of TERT promoter mutations has been changed to the preoperative diagnosis and prognosis of TC, according to their high prevalence in aggressive TC. We searched Pubmed, Web of Science, Scopus, and VHL and reviewed the most common 2 mutations C288T and C250T in different types of TC, the association between them and some specific clinicopathological features, and their significance in preoperative diagnosis and prognosis of TC. we chose 38 studies into our qualitative research. We also chose 22 studies to do a meta-analysis on this subject. The overall rate of these mutations in different types of TC was 10.0%, with 86.1% C228T mutation, 12% C250T mutation, and 2.1% other type mutations. The rate increases significantly as the TC become more aggressive, and reaches 56.8% in anaplastic thyroid cancer (ATC). Statistically meaningful association is found between TERT promoter mutations and older age, larger tumor size, extrathyroidal extension, lymph node metastasis, distance metastasis, advanced TNM stage...Continue Reading

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Citations

May 28, 2019·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·C C Juhlin
Mar 16, 2019·The Journal of Clinical Endocrinology and Metabolism·R Michael Tuttle, Ali S Alzahrani
Sep 27, 2019·Experimental and Therapeutic Medicine·Zongjuan LiLijuan Zou
Sep 30, 2020·Bulletin of Experimental Biology and Medicine·V A KachkoG A Mel'nichenko
Aug 28, 2020·Frontiers in Oncology·Lidia Maria Rebolho Batista ArantesRui Manuel Reis
Aug 17, 2019·Frontiers in Endocrinology·Eleonora MontiMassimo Giusti
Apr 3, 2021·Therapeutic Advances in Endocrinology and Metabolism·Latoya A Stewart, Jennifer H Kuo

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Methods Mentioned

BETA
biopsy

Software Mentioned

Scopus

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