The role of TGFβ in hematopoiesis and myeloid disorders

Leukemia
Alex BatallerGuillermo Garcia-Manero

Abstract

The role of transforming growth factor-β (TGFβ) signaling in embryological development and tissue homeostasis has been thoroughly characterized. Its canonical downstream cascade is well known, even though its true complexity and other non-canonical pathways are still being explored. TGFβ signaling has been described as an important pathway involved in carcinogenesis and cancer progression. In the hematopoietic compartment, the TGFβ pathway is an important regulator of proliferation and differentiation of different cell types and has been implicated in the pathogenesis of a diverse variety of bone marrow disorders. Due to its importance in hematological diseases, novel inhibitors of this pathway are being developed against a number of hematopoietic disorders, including myelodysplastic syndromes (MDS). In this review, we provide an overview of the TGFβ pathway, focusing on its role in hematopoiesis and impact on myeloid disorders. We will discuss therapeutic interventions with promising results against MDS.

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Citations

May 23, 2020·Haematologica·Eva Hellström-LindbergPeter Greenberg
Jan 9, 2020·The New England Journal of Medicine·Pierre FenauxAlan F List
Aug 4, 2020·American Journal of Hematology·Guillermo Garcia-ManeroGuillermo Montalban-Bravo
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Dec 15, 2020·Journal of Cellular and Molecular Medicine·Hongyu ZhaoWentao Yue
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Nov 18, 2020·Stem Cell Research & Therapy·Mohsen EbrahimiMaryam Farzaneh
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Methods Mentioned

BETA
GTPases
acetylation
antisense oligonucleotides
MDS
transfection
MDSs

Clinical Trials Mentioned

NCT01749514
NCT02631070
NCT01736683
NCT02008318
NCT03074006
NCT02268383
NCT01749540
NCT01571635
NCT02604433
NCT00709540

Software Mentioned

MEDALIST

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