PMID: 8611017Feb 13, 1996Paper

The role of Th1 and Th2 cells for mucosal IgA responses

Annals of the New York Academy of Sciences
M YamamotoJ R McGhee

Abstract

We have used cytokine-knockout mice to help determine the precise requirements for CD4+ Th cell regulation of IgA responses. In these studies, we have used two different oral delivery systems to induce mucosal and systemic antibody responses to the vaccine TT. In normal mice, oral administration of TT with CT as adjuvant induces Th2 cells and cytokines, which give rise to mucosal IgA and serum IgG1, IgA, and IgE responses. On the other hand, oral immunization with rSalmonella expressing Tox C results in Th1-type responses as well as Th2 cell-derived IL-10 and macrophage-derived IL-6, which correlate with mucosal IgA and serum IgG2a antibody responses. Two major conclusions can be drawn from our studies with these two regimens in normal, IFN-gamma-/-, and IL-4-/- mice. First, oral administration of rSalmonella, which elicits classical Th1-type responses also induces significant mucosal IgA responses when given to mice with defective Th1- (IFN-gamma-/-) or Th2- (IL-4-/-) cytokine pathways. Interestingly, we detect Th2-type cells producing IL-10 and macrophage-secreting IL-6 in both normal and cytokine-deficient mice, and we postulate that these two cytokines are of most importance for murine IgA responses. Second, oral administra...Continue Reading

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Citations

Mar 26, 1999·European Journal of Immunology·A NollI B Autenrieth
Sep 17, 2009·Immunologic Research·Yasmin Thanavala, Amit A Lugade
May 20, 1998·Research in Immunology·B L Kelsall, W Strober
Jul 1, 1997·Nature Biotechnology·J D Clements
Jun 16, 2010·The Journal of Experimental Medicine·Jae-Kwang YooEleanor N Fish
Nov 16, 2010·Veterinary Immunology and Immunopathology·D Mark Estes
Apr 19, 2012·PLoS Pathogens·Douglas M HeithoffMichael J Mahan
Mar 1, 2005·Vaccine·L C Freytag, J D Clements
Sep 14, 2007·Stress : the International Journal on the Biology of Stress·Robyn M LucasKeith Dear
Nov 19, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Rebecca A BuschKenneth A Kudsk
Nov 11, 2003·Canadian Journal of Physiology and Pharmacology·J QuadrilateroL Hoffman-Goetz
Apr 9, 2005·Parasite Immunology·Rafael Campos-Rodríguezp, Adriana Jarillo-Luna
Jul 3, 2019·Medical Microbiology and Immunology·Yien Shin TohChun Wie Chong
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark A EndsleyD Mark Estes
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Constantine BitsaktsisEdmund J Gosselin
Jun 17, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Maoxiang LiJames Pestka

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