Abstract
CD4 + Th1-CXCR3 signalling pathway may play a key role in chronic obstructive pulmonary disease (COPD). The aim of this study was to explore Th1/Th2 cytokines ratio differences in patients in different stages of COPD and to confirm the hypothesis that elastin exposure might serve as an antigen to initiate the stimulation of CD4 + Th1-CXCR3 immune inflammation pathway. Patients of COPD in different stages and normal individuals were enrolled. Ten millilitres of peripheral blood was drawn from patients. The concentration of CXCR3, IFN-γ, IL-2, IL-4 and IL-13 in plasma was detected by ELISA. The Naïve CD4+ T cells were isolated from the peripheral blood mononuclear cells, which were stimulated by elastin and collagen before determining the level of IFN-γ secretion by ELISPOT. Compared with control group, the concentration of CXCR3 in the acute exacerbation COPD (AECOPD) group was higher (P < .05). The concentration of IFN-γ and IL-2 in AECOPD group was lower than that in remission (P < .05). The concentration of IFN-γ in the AECOPD and remission was higher than that in controls (P < .05), while IL-2 was opposite (P < .01). The concentration of IL-4 and IL-13 in AECOPD group was higher than that in the controls (P < .05). The CD4+ ...Continue Reading
References
Aug 3, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S Romagnani
Apr 20, 2005·Advances in Protein Chemistry·Suzanne M Mithieux, Anthony S Weiss
Sep 24, 2005·American Journal of Respiratory and Critical Care Medicine·John R HurstJadwiga A Wedzicha
Feb 18, 2006·American Journal of Respiratory and Critical Care Medicine·Alberto PapiSebastian L Johnston
Apr 24, 2007·Nature Medicine·Seung-Hyo LeeFarrah Kheradmand
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·Carol A Feghali-BostwickSteven R Duncan
Nov 13, 2007·Respiratory Research·Maria TorvinenIain Kilty
Nov 4, 2008·The European Respiratory Journal·M LuisettiG M Turino
Feb 17, 2009·American Journal of Respiratory and Critical Care Medicine·Steven G KelsenVictor Kim
Apr 10, 2009·The European Respiratory Journal·G DesleeR A Pierce
May 1, 2010·The Journal of Allergy and Clinical Immunology·Manisha SinghFarrah Kheradmand
Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Mar 8, 2011·Experimental Cell Research·Joanna R Groom, Andrew D Luster
Mar 19, 2011·Chest·Natalie SlowikGerard M Turino
Jul 2, 2014·Scientific Reports·Chun ChangJiangchao Zhao
Jan 13, 2015·Disease Models & Mechanisms·Vincenzo TorracaAnnemarie H Meijer
Jun 14, 2015·Cytokine·Naina Gour, Marsha Wills-Karp
Jun 19, 2015·World Journal of Hepatology·Roli Saxena, Jyotdeep Kaur
Nov 30, 2016·PloS One·Karl J StaplesTom M A Wilkinson
Jan 28, 2017·American Journal of Respiratory and Critical Care Medicine·Claus F VogelmeierAlvar Agustí
Citations
Dec 12, 2019·Journal of Tissue Engineering and Regenerative Medicine·Claudia BilodeauMartin Post
Jul 20, 2019·Mediators of Inflammation·Min JiangJianbing Ding
Jul 12, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Aurélie Le PageTamas Fulop
Jan 14, 2021·Respiratory Research·Flora LemaireRichard Le Naour
Nov 6, 2020·International Journal of Environmental Research and Public Health·Kulothungan GunasekaranArul Chandran
Apr 16, 2021·ERJ Open Research·Mathieu FieldesArnaud Bourdin
May 22, 2021·The Journal of International Medical Research·Jun ZhouFeng Wu
Aug 7, 2021·Frontiers in Immunology·Min JiangJianbing Ding