PMID: 18202594Jan 19, 2008Paper

The role of the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) in cardiovascular diseases

Postȩpy higieny i medycyny doświadczalnej
Andrzej BodułaRajmund Adamiec

Abstract

Aldosterone plays an important role in the regulation of electrolyte and water homeostasis and in blood pressure maintenance. The latest studies have revealed involvement of this hormone in the development of myocardium hypertrophy and fibrosis, with heart failure progression, vessel remodeling, and atherogenesis. The crucial enzyme in aldosterone production is aldosterone synthase, which catalyses the last three steps of its synthesis. It was reported in many studies that polymorphisms of the gene encoding aldosterone synthase, CYP11B2, especially the -344C/T polymorphism, are associated with cardiovascular diseases. This article is a short review of research on the role of the CYP11B2-344C/T polymorphism in hypertension, heart muscle remodeling, and especially in atherogenesis. Information about the molecular basis of aldosterone's synthesis, action, and significance, especially in heart failure, is also provided.

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.