PMID: 8584619Oct 1, 1995Paper

The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion

Psychopharmacology
D FiorellaJ C Winter

Abstract

The present study was designed to determine the effects of p-chlorophenylalanine (PCPA) and p-chloroamphetamine (PCA) administration on (1) the levels of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rat brain, (2) the sensitivity of LSD-trained rats to the stimulus effects of LSD, and (3) the maximal levels of 5-HT2A and 5-HT2C receptor mediated phosphoinositide (PI) hydrolysis in rat brain. PCA and PCPA both produced a significant depletion of whole brain 5-HT and 5-HIAA concentrations. The depletion of serotonin with PCPA, but not PCA, resulted in supersensitivity of LSD-trained subjects to the stimulus effects of LSD. Neither PCPA nor PCA treatment altered the maximal level of 5-HT2A receptor-mediated PI hydrolysis. However, PCPA, but not PCA, treatment resulted in a significant upregulation (46%, P < 0.05) of the maximal level of 5-HT2C receptor mediated PI hydrolysis. These data suggest that upregulation of the 5-HT2C receptor mediates the supersensitivity to LSD discriminative stimulus which follows the depletion of central nervous system serotonin by PCPA.

References

Jul 1, 1976·Pharmacology, Biochemistry, and Behavior·J A Joseph, J B Appel
Mar 7, 1975·Science·J A HarveyL M Yunger
May 1, 1975·Pharmacology, Biochemistry, and Behavior·R G Browne, B T Ho
Apr 30, 1975·Psychopharmacologia·T U JärbeB G Henriksson
May 1, 1977·Pharmacology, Biochemistry, and Behavior·J A Joseph, J B Appel
Jun 12, 1978·Annals of the New York Academy of Sciences·J L Meek
Jun 12, 1978·Annals of the New York Academy of Sciences·K FuxeJ A Gustafsson
Jun 12, 1978·Annals of the New York Academy of Sciences·C KöhlerS O Ogren
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·I Lucki
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·R A Glennon, M Dukat
Aug 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·I Sahin-ErdemliD Hoyer
Jun 12, 1990·European Journal of Pharmacology·I van WijngaardenW Soudijn
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·R A Glennon, A E Hauck
Jan 6, 1987·Brain Research·P J ConnE Sanders-Bush
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·F J WhiteJ B Appel
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·J B AppelA M Holohean
Dec 17, 1981·European Journal of Pharmacology·M A BlackshearE Sanders-Bush
May 1, 1993·Pharmacology, Biochemistry, and Behavior·J C Winter, R A Rabin
Jun 1, 1964·Biochemical Pharmacology·J B APPEL, D X FREEDMAN

❮ Previous
Next ❯

Citations

Jul 19, 2006·Psychopharmacology·Ronald L Cowan
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·J C WinterR A Rabin
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R A Glennon
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·J C WinterR A Rabin
Jul 31, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·S HelsleyJ C Winter
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·S HelsleyJ C Winter
Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam L HalberstadtSusan B Powell
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·H R KranzlerT F Babor
Sep 23, 2010·The Journal of Pharmacology and Experimental Therapeutics·W E FantegrossiJ H Woods
Nov 4, 2000·Journal of Psychoactive Drugs·M C McBride
Aug 11, 2007·Pharmacology, Biochemistry, and Behavior·J C WinterR A Rabin
Feb 8, 2006·Pharmacology, Biochemistry, and Behavior·W E FantegrossiJ H Woods
Jun 24, 2005·Pharmacology, Biochemistry, and Behavior·M M Doat-MeyerhoeferR A Rabin
Feb 11, 2015·The Canadian Journal of Cardiology·Andrea Pucci, Nicholas Finer
Nov 26, 2016·International Journal of Molecular Sciences·Danilo De GregorioGabriella Gobbi
May 3, 2014·Therapeutic Advances in Chronic Disease·Sean ManningNicholas Finer
Mar 30, 2004·Anais Da Academia Brasileira De Ciências·Hawlinston R C LimaLuís C Reis
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.