The role of the adapter molecule SLP-76 in platelet function

Oncogene
B A Judd, G A Koretzky

Abstract

Following vascular injury, one of the most critical initial events is activation of platelets followed by formation of a hemostatic plug. Platelets are capable of responding to a diverse array of agonists resulting in adhesion and granule release. The biochemical events underlying platelet activation are just beginning to be understood. One class of molecules shown to play important roles in this process is adapters. Adapter molecules contain distinct modular domains which mediate protein-protein or protein-lipid interactions giving these proteins the ability to nucleate signal transduction complexes. In this review we will discuss the function of the hematopoietic cell specific adapter molecule, SLP-76 in both platelet activation and hemostasis. Because many parallels exist between signal transduction pathways in platelets and lymphocytes, we will also review the function of SLP-76 in coordinating signal transduction pathways following antigen bind to the T cell receptor.

References

Mar 15, 1992·The Biochemical Journal·M H WernerY A Hannun
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Jun 1, 1989·The Australian and New Zealand Journal of Surgery·K G MountjoyI M Holdaway
Mar 30, 1989·Nature·M Reth
Jan 1, 1985·Advances in Experimental Medicine and Biology·M CastagnaS Levy-Toledano
Apr 1, 1982·Metabolism: Clinical and Experimental·R D Steele
Dec 1, 1982·Digestive Diseases and Sciences·W VielhauerW Sonntag
Mar 31, 1995·The Journal of Biological Chemistry·J K JackmanP R Findell
Feb 1, 1994·Current Opinion in Genetics & Development·J Schlessinger
Jul 16, 1993·Cell·D Bar-SagiJ Schlessinger
Jan 1, 1996·Pediatric Radiology·S A Al-RasheedN A Al-Jurayyan
Jul 26, 1996·The Journal of Biological Chemistry·J GibbinsS P Watson
Mar 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N C BirdA G Johnson
Aug 16, 1996·The Journal of Biological Chemistry·J Bubeck WardenburgP R Findell
Jan 1, 1996·Progress in Biophysics and Molecular Biology·M Sudol
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J da SilvaC E Rudd
Mar 26, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·I HersJ W Akkerman

❮ Previous
Next ❯

Citations

Aug 16, 2002·Transplant Immunology·Friedemann KieferRuediger Arnold
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Robert Goggs, Alastair W Poole
Nov 16, 2004·Seminars in Immunology·Jennifer N Wu, Gary A Koretzky
Mar 2, 2016·Journal of Thrombosis and Haemostasis : JTH·A P ByeJ M Gibbins
Oct 1, 2004·The Journal of Biological Chemistry·Andrew C PearceElena Vigorito
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiao-Ping ZhongGary A Koretzky
Aug 1, 2020·Scandinavian Journal of Immunology·Paweł BorowiczAnne Spurkland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.