The Role of the Atrial Electromechanical Delay in Predicting Atrial Fibrillation in Myotonic Dystrophy Type 1 Patients

Journal of Cardiovascular Electrophysiology
Vincenzo RussoGerardo Nigro

Abstract

Paroxysmal atrial tachyarrhythmias frequently occur in myotonic dystrophy type 1 (DM1) patients. The aim of the current study was to evaluate the atrial electromechanical-delay (AEMD) in a DM1-population with normal cardiac function and its relationship to atrial fibrillation (AF) onset. Fifty DM1 patients (28 male; mean age 34.2 ± 11.4 years) and 50 healthy subjects used as controls, matched for age and gender, were studied for the occurrence of atrial fibrillation during a 4-year follow-up, through 30-day external loop recorder (ELR) monitoring performed every 6 months. Intra-AEMD and inter-AEMD of both atrium were measured through tissue-Doppler echocardiography. Compared to the healthy control group, the DM1 group showed a statistically significant increase in inter-AEMD and intraleft-AEMD. Dividing the DM1-group into 2 subgroups (patients with or without AF), the inter-AEMD and intraleft-AEMD were significantly higher in the subgroup with AF compared to the subgroup without AF. A cut off value of 39.2 milliseconds for intraleft-AEMD had a sensitivity of 90% and a specificity of 90% in identifying DM1 patients with AF risk. A cut off value of 57.7 milliseconds for inter-AEMD had a sensitivity of 84.2% and a specificity of 9...Continue Reading

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Citations

Nov 4, 2016·Pacing and Clinical Electrophysiology : PACE·Vincenzo RussoGerardo Nigro
Mar 1, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Vincenzo RussoGerardo Nigro
Nov 24, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Anna RagoGerardo Nigro
Feb 16, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Lukas ChmielewskiAnca-Rezeda Florian
Jul 28, 2020·Circulation Research·M Benjamin ShoemakerMarco V Perez
Dec 8, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Matteo GaribaldiGiovanni Antonini
Feb 13, 2021·Neuromuscular Disorders : NMD·Vincenzo RussoGerardo Nigro
Aug 16, 2019·Journal of Cardiac Failure·Vincenzo RussoGerardo Nigro

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