The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations

Scientific Reports
Fernando dos SantosMaria-Cláudia Irigoyen

Abstract

It is well-established that baroreflex sensitivity is essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate the role of the baroreflex in the cardiometabolic and inflammatory derangements promoted by fructose overload, Wistar rats underwent sinoaortic denervation (SAD) or sham surgery and were studied 90 days after receiving tap water (Den and Ctrl) or a 10% fructose solution (Fruc and Den-Fruc). All experimental groups showed marked and similar degree of baroreflex impairment compared to Ctrl. As expected, fructose overload effectively induced metabolic syndrome; however, when it was associated with SAD, several alterations were attenuated. While Fruc rats displayed increased sympathetic modulation and tone and reduced vagal modulation compared to Ctrl animals, Den-Fruc rats showed greater vagal tone and modulation when compared to the Fruc group. Moreover, the Den-Fruc group showed augmented expression of β1 adrenergic receptors and TNF/IL-10 ratio and reduction of β2 in the left ventricle. The increase in vagal function was correlated with improved insulin sensitivity (r2 = 0.76), and decreased abdominal fat (r2 = -0.78) and β2 rece...Continue Reading

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Citations

Dec 15, 2020·Scientific Reports·Nathalia Juocys Dias MoreiraMaria Cláudia Costa Irigoyen
Mar 12, 2021·Journal of Applied Physiology·Cynthia R MullerPedro Cabrales
Aug 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhe-Bin ChengChi Zhang

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

Image J®
Windaq
DataQ
Cardioseries®
Den

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