The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke.

Advances in Experimental Medicine and Biology
Martha E O'DonnellSteven E Anderson

Abstract

Studies from this and other laboratories have shown that the Na-K-2Cl cotransporter is present in BBB endothelial cells is stimulated by factors present during cerebral ischemia. Further, our in situ studies have shown that the cotransporter resides predominantly in the luminal BBB membrane. This is consistent with the hypothesis that a luminal cotransporter works with abluminal Na/K ATPase to secrete NaCl into the brain, and during stroke, BBB cotransporter activity is increased such that the barrier hypersecretes NaCl and water into the brain, facilitating cytotoxic edema formation. Our in vivo MCAO stroke studies provide further support for a role of the BBB cotransporter in cerebral ede-ma formation. Collectively, these findings suggest that the BBB Na-K-2Cl cotransporter does indeed substantially contribute to cerebral edema formation in stroke.

Citations

Apr 8, 2011·American Journal of Physiology. Cell Physiology·Jennifer M RutkowskyMartha E O'Donnell
Jul 11, 2012·International Journal of Cell Biology·Vincent BerezowskiJérôme Badaut
Oct 18, 2012·Physiological Reviews·Kenneth B Gagnon, Eric Delpire
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jesse A StokumJ Marc Simard
Nov 1, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mohammad Iqbal H BhuiyanDandan Sun
Feb 19, 2011·Nature Reviews. Neuroscience·Edward A NeuweltLester R Drewes
Jul 6, 2014·Neurochemical Research·Jesse A StokumJ Marc Simard

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