The role of the blood-brain barrier transporter PTS-1 in regulating concentrations of methionine enkephalin in blood and brain

Alcohol
W A Banks, A J Kastin

Abstract

Previous studies have suggested that peptide transport system (PTS)-1, a saturable efflux system from brain to blood, regulates the concentration in the brain of methionine enkephalin (Met-Enk), an opiate peptide related to the drinking of ethanol in mice. We determined the relationship of PTS-1 to concentrations of immunoreactive Met-Enk in plasma and whole brain in eight randomly selected strains of mice. An active PTS-1 system could be demonstrated in five of the eight strains. In those five strains, faster efflux rates due to PTS-1 correlated with higher concentrations of Met-Enk in brain and plasma. These concentrations of Met-Enk in brain and plasma were positively correlated in the five strains in which PTS-1 was demonstrable and were inversely correlated in the three strains in which PTS-1 was not demonstrable. The results are consistent with previous observations indicating that the chronic level of brain Met-Enk can set the level of activity of PTS-1 and that, once set, PTS-1 can play a major role in determining the concentrations of Met-Enk in brain and blood.

References

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Citations

May 7, 2004·Peptides·William A BanksMichael L Niehoff
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·S R PlotkinA J Kastin
Aug 1, 2006·Neurologic Clinics·William A Banks
May 29, 2004·Alcoholism, Clinical and Experimental Research·William A BanksJohn E Morley
Apr 25, 2009·Immunology and Allergy Clinics of North America·William A Banks
Apr 28, 2009·Progress in Neurobiology·Ivona BrasnjevicUNKNOWN European NanoBioPharmaceutics Research Initiative
May 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Naoko NonakaWilliam A Banks
Feb 1, 2000·The Journal of Biological Chemistry·M HauserJ M Becker

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