The role of the BRCA2 gene in susceptibility to prostate cancer revisited.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Elaine A Ostrander, Miriam S Udler

Abstract

Prostate cancer is a genetically complex disease with multiple predisposing factors affecting presentation, progression, and outcome. Epidemiologic studies have long shown an aggregation of breast and prostate cancer in some families. More recently, studies have reported an apparent excess of prostate cancer cases among BRCA2 mutation-carrying families. Additionally, population-based screens of early-onset prostate cancer patients have suggested that the prevalence of deleterious BRCA2 mutations in this group is 1% to 2%, imparting a significantly increased risk of the disease compared with noncarrier cases. However, studies of high-risk prostate cancer families suggest that BRCA2 plays at most a minimal role in these individuals, highlighting the potential genetic heterogeneity of the disease. In this commentary, we review the current literature and hypotheses surrounding the relationship between BRCA2 mutations and susceptibility to prostate cancer and speculate on the potential for involvement of additional genes.

References

Oct 10, 1992·BMJ : British Medical Journal·H TuliniusH Sigvaldason
Jul 15, 1992·Journal of the National Cancer Institute·D E Anderson, M D Badzioch
Dec 21, 1994·Journal of the National Cancer Institute·T A SellersA R Folsom
Sep 1, 1993·The Journal of Urology·B S CarterP C Walsh
Jul 1, 1993·Cancer·D E Anderson, M D Badzioch
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
Jul 1, 1997·American Journal of Human Genetics·D F EastonD E Goldgar
Aug 5, 1999·Journal of the National Cancer Institute·UNKNOWN Breast Cancer Linkage Consortium
Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O JohannssonH Olsson
May 23, 2000·American Journal of Human Genetics·M GibbsL Hood
Feb 15, 2001·American Journal of Human Genetics·D ThompsonUNKNOWN Breast Cancer Linkage Consortium
Jul 13, 2002·Journal of Medical Genetics·H TuliniusJ E Eyfjord
Dec 11, 2002·American Journal of Human Genetics·Stephen M EdwardsUNKNOWN British Association of Urological Surgeons Section of Oncology
Jun 7, 2003·Endocrine-related Cancer·J SimardS V Tavtigian
Nov 6, 2003·The Prostate·Douglas F EastonUNKNOWN International Consortium for Prostate Cancer Genetics
Nov 6, 2003·The Prostate·Marta JanerGail P Jarvik
Jan 30, 2004·Human Molecular Genetics·Daniel J Schaid
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander LiedeSteven A Narod
Mar 31, 2004·American Journal of Epidemiology·Ko-Hui TungLaurence N Kolonel
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomas KirchhoffKenneth Offit
May 8, 2004·Familial Cancer·Jan LubinskiSteven A Narod
Nov 20, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Lorenzo Bermejo, K Hemminki
Sep 6, 2005·Journal of Medical Genetics·C J van AsperenUNKNOWN Netherlands Collaborative Group on Hereditary Breast Cancer (HEBON)
Nov 2, 2005·Breast Cancer Research and Treatment·Marcela GallardoPilar Carvallo
Mar 23, 2006·JAMA : the Journal of the American Medical Association·Tom WalshMary-Claire King

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Citations

Nov 11, 2009·Cancer Causes & Control : CCC·Ilir AgalliuJanet L Stanford
Jan 13, 2012·The New England Journal of Medicine·Charles M EwingKathleen A Cooney
Jul 29, 2011·Substance Abuse Treatment, Prevention, and Policy·Tina Van HavereMark Bellis
May 30, 2009·BMC Research Notes·Kristina Allen-BradyLisa A Cannon-Albright
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Apr 8, 2011·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Danny VespriniRobert G Bristow
Apr 4, 2012·European Urology·Thomas Bessede, Jean-Jacques Patard
Sep 18, 2009·The Journal of Urology·Monique J RoobolGerald L Andriole
Jul 21, 2009·Primary Care·Larissa A Korde, Shahinaz M Gadalla
Nov 11, 2010·International Journal of Cancer. Journal International Du Cancer·Riikka NurminenJohanna Schleutker
Aug 18, 2012·The Breast Journal·Tara Mahar, David G Hicks
Jun 6, 2013·Prostate Cancer·Henrique B da SilvaRicardo G Correa
Jun 2, 2016·Nature Reviews. Clinical Oncology·Daniel E SprattScott A Tomlins
Oct 18, 2016·The Cancer Journal·Daniel H Hovelson, Scott A Tomlins
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria M RaymondStephen B Gruber
Nov 22, 2018·Clinical Chemistry·Richard J Fantus, Brian T Helfand
Feb 16, 2018·Human Mutation·Timothy R RebbeckKatherine L Nathanson
Mar 22, 2020·Cancers·Jacob J AdashekPavlos Msaouel
Feb 2, 2020·Cellular and Molecular Life Sciences : CMLS·Sevda JafariFarhad Jadidi-Niaragh

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