PMID: 6540323Jun 1, 1984Paper

The role of the catecholaminergic mechanism in foot shock (FS) stress- and immobilized-water immersion (IW) stress-induced analgesia in mice

Japanese Journal of Pharmacology
M TakahashiH Kaneto

Abstract

Involvement of the catecholaminergic mechanism in foot shock (FS)- and immobilized-water immersion (IW)-stress-induced analgesia (SIA) and in the development of tolerance to the effect were investigated in mice. With daily treatment with clonidine or daily exposure to stresses, tolerance developed rapidly to the analgesic effect. Clonidine-induced analgesia, which could not be antagonized by naloxone, was potentiated in the animals rendered tolerant to FS-stress, and it was attenuated in the animals tolerant to IW-SIA. On the other hand, animals tolerant to clonidine failed to show the attenuation of FS- and IW-SIA. The analgesic effect of clonidine and the development of tolerance to the effect were not influenced by reserpine. However, reserpine pretreatment completely suppressed the analgesic effect induced by FS- and IW-stresses on the 1st day; but with daily exposure to the stress, the analgesic effect gradually appeared and returned to the control level on the 5th day. These results indicate not only the differences between clonidine analgesia and SIAs but also those between each SIA. Thus, the central catecholaminergic mechanisms play an important role in these SIAs and also in the development of tolerance to the effect,...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.