PMID: 11902551Mar 21, 2002Paper

The role of the coagulation system in tumour angiogenesis

The Lancet Oncology
G F NashA K Kakkar

Abstract

The coagulation system, which is activated in most cancer patients, has an important role in tumour biology. It may make a substantial contribution to tumour angiogenesis, which represents an imbalance in the normal mechanisms that allow organised healing after injury. The recently recognised, but steadily growing, knowledge of the relationship between the coagulation and angiogenesis pathways has research and clinical implications. Manipulation of these systems may minimise both the neoangiogenesis essential for tumour growth and associated thromboembolic complications. However, since surgery is the primary treatment for most cancers, the angiogenesis of wound healing and haemostatic competence must be maintained. In this article, we summarise the complex interactions between the coagulation system and the angiogenic process that occur in cancer growth. We focus upon the contributions of the vascular endothelium, platelets, and coagulation factors to the angiogenic process and explore the coagulation system as a therapeutic target.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E BacharachE Keshet
Jan 1, 1992·Seminars in Thrombosis and Hemostasis·L R ZacharskiV A Memoli
May 15, 1992·Biochemical and Biophysical Research Communications·K UsukiC H Heldin
Jan 1, 1991·The Journal of Clinical Investigation·M L NierodzikS Karpatkin
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T NakamuraA Ichihara
Jan 1, 1984·Cancer Metastasis Reviews·G J Gasic
Sep 1, 1994·The Journal of Clinical Investigation·Y ZhangP P Nawroth
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SuehiroK Sugimachi
Sep 5, 1996·Nature·P CarmelietD Collen
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Apr 29, 1998·The Journal of Clinical Investigation·Y ZhangP P Nawroth
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·O V VolpertN P Bouck
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·R CaoY Cao
Oct 3, 1999·The Journal of Biological Chemistry·M S O'ReillyM A Moses
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·M StreitM Detmar
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A ReijerkerkM F Gebbink
Mar 18, 2008·Diabetes Research and Clinical Practice·C M ThomasB A Leatherdale

❮ Previous
Next ❯

Citations

Sep 27, 2005·Digestive Diseases and Sciences·Rafael PeriniLi Ma
Jan 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Vijay G PeddareddigariRaymond N Dubois
Mar 17, 2004·Seminars in Cancer Biology·Janusz Rak, Joanne L Yu
Jun 27, 2003·Microvascular Research·Barden ChanVikas P Sukhatme
Jun 12, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J Lykke, H J Nielsen
Aug 2, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ozgur Mete, Sylvia L Asa
Jan 19, 2005·Retina·Glenn L Stoller, Shaker A Mousa
Sep 3, 2005·Oncology·József TímárKároly Lapis
Mar 21, 2002·The Lancet Oncology·G SchwartsmannI Roisemberg
Jul 27, 2002·The Lancet Oncology·G F NashA K Kakkar
Dec 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Li MaJohn L Wallace
May 28, 2014·Thrombosis Research·Simon Noble
Jun 15, 2012·Thrombosis Research·Delphine GarnierJanusz Rak
May 15, 2010·Thrombosis Research·Cornelis J F Van NoordenC Arnold Spek
Nov 21, 2007·Thrombosis Research·Virginie TerraubeCécile V Denis
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yvonne FörsterBernd Schwenzer
Dec 17, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jong-Mu SunMyung-Ju Ahn
Dec 17, 2003·Journal of Thrombosis and Haemostasis : JTH·A A Khorana
Dec 3, 2003·Expert Opinion on Pharmacotherapy·Agnes Y Y Lee
May 17, 2014·Platelets·Tony G WalshMichael C Berndt
Oct 25, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kellen L MeadowsHerbert I Hurwitz
Dec 10, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezJuan Pedro Kusanovic
Feb 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agnes Y Y LeeMark N Levine
May 20, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezSonia S Hassan
Oct 8, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andréia BuffonJoão J F Sarkis
May 25, 2007·Nature Reviews. Cancer·Henk M W Verheul, Herbert M Pinedo
Aug 2, 2007·Journal of Cellular Biochemistry·Shinichi SakamotoNatasha Kyprianou
Dec 6, 2005·Molecular and Cellular Biochemistry·Andréia BuffonJoão J F Sarkis
Mar 28, 2008·American Journal of Physiology. Cell Physiology·Panagiota ZaniaNikos E Tsopanoglou
Aug 14, 2008·Expert Review of Anticancer Therapy·Lubor Borsig
Jul 9, 2004·American Journal of Physiology. Cell Physiology·Karen LawlerDermot Kenny
Nov 27, 2004·Journal of Surgical Oncology·Jakob Lykke, Hans Jørgen Nielsen
Oct 3, 2007·Biological Research for Nursing·Bashir A LwaleedKathryn Getliffe
Apr 22, 2003·Pathology Oncology Research : POR·József TímárLászló Kopper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.