The role of the common gamma-chain family cytokines in γδ T cell-based anti-cancer immunotherapy

Cytokine & Growth Factor Reviews
Heleen H Van AckerViggo F Van Tendeloo

Abstract

Cytokines of the common gamma-chain receptor family, comprising interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15 and IL-21, are vital with respect to organizing and sustaining healthy immune cell functions. Supporting the anti-cancer immune response, these cytokines inspire great interest for their use as vaccine adjuvants and cancer immunotherapies. It is against this background that gamma delta (γδ) T cells, as special-force soldiers and natural contributors of the tumor immunosurveillance, also received a lot of attention the last decade. As γδ T cell-based cancer trials are coming of age, this present review focusses on the effects of the different cytokines of the common gamma-chain receptor family on γδ T cells with respect to boosting γδ T cells as a therapeutic target in cancer immunotherapy. This review also gathers data that IL-15 in particular exhibits key features for augmenting the anti-tumor activity of effector killer γδ T cells whilst overcoming the myriad of immune escape mechanisms used by cancer cells.

Citations

Jun 21, 2019·Expert Opinion on Biological Therapy·Elena Lo PrestiSerena Meraviglia
Jul 22, 2020·Immunological Reviews·Elena Lo PrestiSerena Meraviglia
Jul 24, 2020·Cellular & Molecular Immunology·Dieter KabelitzShirin Kalyan
May 21, 2021·Journal for Immunotherapy of Cancer·Lingling OuXiaowei Xu
Aug 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jian SunZhaowei Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Immunological Reviews
Devangi S MehtaMichael J Grusby
Annals of the New York Academy of Sciences
Neela S Bhave, William E Carson
Cytokine & Growth Factor Reviews
Suresh PallikkuthSavita Pahwa
© 2022 Meta ULC. All rights reserved